(+/-)-1-[4-(tert-butyldiphenylsilanoxymethyl)phenyl]-4-(trimethylsilanyl)-but-3-yn-1-ol

Base Information

Chemical Name:(+/-)-1-[4-(tert-butyldiphenylsilanoxymethyl)phenyl]-4-(trimethylsilanyl)-but-3-yn-1-ol
CAS No.:475160-73-7
Molecular Formula:C₃₀H₃₈O₂Si₂
Molecular Weight:486.802
Hs Code.:

Synonyms:(+/-)-1-[4-(tert-butyldiphenylsilanoxymethyl)phenyl]-4-(trimethylsilanyl)-but-3-yn-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-1-[4-(tert-butyldiphenylsilanoxymethyl)phenyl]-4-(trimethylsilanyl)-but-3-yn-1-ol

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Technology Process of (+/-)-1-[4-(tert-butyldiphenylsilanoxymethyl)phenyl]-4-(trimethylsilanyl)-but-3-yn-1-ol

There total 4 articles about (+/-)-1-[4-(tert-butyldiphenylsilanoxymethyl)phenyl]-4-(trimethylsilanyl)-but-3-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 38002-45-8
3-bromo-1-(trimethylsilyl)-1-propyne

: 196880-47-4
4-({[tert-butyl(diphenyl)silyl]oxy}methyl)benzaldehyde

: 475160-73-7
(+/-)-1-[4-(tert-butyldiphenylsilanoxymethyl)phenyl]-4-(trimethylsilanyl)-but-3-yn-1-ol

Guidance literature:: With (3S,3aS,4S,4aS,6S,8aR,8bR,11S)-6,11-dihydroxy-3-methyl-12-methylene-2-oxo-4a,6-ethano-3,8b-prop-1-enoperhydroindeno[1,2-b]furan-4-carboxylic acid; potassium iodide; lithium chloride; In tetrahydrofuran; at 60 ℃; for 14h;
DOI:10.1021/ol016915f

Reference yield:

: 589-29-7
p-xylylene glycol

: 475160-73-7
(+/-)-1-[4-(tert-butyldiphenylsilanoxymethyl)phenyl]-4-(trimethylsilanyl)-but-3-yn-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / imidazole / dimethylformamide / 24 h

2: 74 percent / N-methylmorpholine oxide / RuCl₂(PPh₃)3 / acetone / 0.42 h

3: 68 percent / LiCl; KI; Ga / tetrahydrofuran / 14 h / 60 °C

With 1H-imidazole; 4-methylmorpholine N-oxide; (3S,3aS,4S,4aS,6S,8aR,8bR,11S)-6,11-dihydroxy-3-methyl-12-methylene-2-oxo-4a,6-ethano-3,8b-prop-1-enoperhydroindeno[1,2-b]furan-4-carboxylic acid; potassium iodide; lithium chloride; tris(triphenylphosphine)ruthenium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol016915f

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 475160-73-7
(+/-)-1-[4-(tert-butyldiphenylsilanoxymethyl)phenyl]-4-(trimethylsilanyl)-but-3-yn-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / imidazole / dimethylformamide / 24 h

2: 74 percent / N-methylmorpholine oxide / RuCl₂(PPh₃)3 / acetone / 0.42 h

3: 68 percent / LiCl; KI; Ga / tetrahydrofuran / 14 h / 60 °C

With 1H-imidazole; 4-methylmorpholine N-oxide; (3S,3aS,4S,4aS,6S,8aR,8bR,11S)-6,11-dihydroxy-3-methyl-12-methylene-2-oxo-4a,6-ethano-3,8b-prop-1-enoperhydroindeno[1,2-b]furan-4-carboxylic acid; potassium iodide; lithium chloride; tris(triphenylphosphine)ruthenium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol016915f