(E)-1-(N-benzyl-N-2'-carboethoxyethylamino)-1-(1-propenyl)cyclopropaneacetonitrile

Base Information

Chemical Name:(E)-1-(N-benzyl-N-2'-carboethoxyethylamino)-1-(1-propenyl)cyclopropaneacetonitrile
CAS No.:193560-63-3
Molecular Formula:C₂₀H₂₆N₂O₂
Molecular Weight:326.439
Hs Code.:

Synonyms:(E)-1-(N-benzyl-N-2'-carboethoxyethylamino)-1-(1-propenyl)cyclopropaneacetonitrile

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Chemical Property of (E)-1-(N-benzyl-N-2'-carboethoxyethylamino)-1-(1-propenyl)cyclopropaneacetonitrile

Chemical Property:

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Technology Process of (E)-1-(N-benzyl-N-2'-carboethoxyethylamino)-1-(1-propenyl)cyclopropaneacetonitrile

There total 3 articles about (E)-1-(N-benzyl-N-2'-carboethoxyethylamino)-1-(1-propenyl)cyclopropaneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 7677-24-9
trimethylsilyl cyanide

: 23583-21-3
ethyl-3-benzylamino propionate

: 193560-62-2
1-(1-propenyl)cyclopropanecarboxaldehyde

: 193560-63-3
(E)-1-(N-benzyl-N-2'-carboethoxyethylamino)-1-(1-propenyl)cyclopropaneacetonitrile

Guidance literature:: With zinc(II) iodide; In ethanol; for 18h; Heating;
DOI:10.1016/S0040-4020(97)90402-6

Reference yield:

: 16529-66-1
3-Pentenenitrile

: 193560-63-3
(E)-1-(N-benzyl-N-2'-carboethoxyethylamino)-1-(1-propenyl)cyclopropaneacetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, DMPU / 1.) THF, hexane, -60 deg C -> -30 deg C, 45 min, 2.) THF, hexane, -65 deg C -> -10 deg C_.

2: 76 percent / DIBAL / diethyl ether; hexane / 3 h / 0 °C

3: 75 percent / ZnI₂ / ethanol / 18 h / Heating

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; diisobutylaluminium hydride; zinc(II) iodide; lithium diisopropyl amide; In diethyl ether; ethanol; hexane;
DOI:10.1016/S0040-4020(97)90402-6

Reference yield:

: 193560-61-1
1-(1-propenyl)cyclopropanecarbonitrile

: 193560-63-3
(E)-1-(N-benzyl-N-2'-carboethoxyethylamino)-1-(1-propenyl)cyclopropaneacetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / DIBAL / diethyl ether; hexane / 3 h / 0 °C

2: 75 percent / ZnI₂ / ethanol / 18 h / Heating

With diisobutylaluminium hydride; zinc(II) iodide; In diethyl ether; ethanol; hexane;
DOI:10.1016/S0040-4020(97)90402-6