N1-[(5-para-toluenesulfonyl)ethoxyethyl]-5'-O-monomethoxytrityl-2',3'-O-isopropylideneinosine

Base Information

• Chemical Name: N1-[(5-para-toluenesulfonyl)ethoxyethyl]-5'-O-monomethoxytrityl-2',3'-O-isopropylideneinosine
• CAS No.: 1232139-79-5
• Molecular Formula: C₄₄H₄₆N₄O₁₀S
• Molecular Weight: 822.936
• Mol file: 1232139-79-5.mol

Synonyms:N1-[(5-para-toluenesulfonyl)ethoxyethyl]-5'-O-monomethoxytrityl-2',3'-O-isopropylideneinosine

Chemical Property of N1-[(5-para-toluenesulfonyl)ethoxyethyl]-5'-O-monomethoxytrityl-2',3'-O-isopropylideneinosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N1-[(5-para-toluenesulfonyl)ethoxyethyl]-5'-O-monomethoxytrityl-2',3'-O-isopropylideneinosine

There total 3 articles about N1-[(5-para-toluenesulfonyl)ethoxyethyl]-5'-O-monomethoxytrityl-2',3'-O-isopropylideneinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N1-[(5-hydroxyl)ethoxyethyl]-5'-O-monomethoxytrityl-2',3'-O-isopropylideneinosine (1232139-77-3) + p-toluenesulfonyl chloride (98-59-9) → N1-[(5-para-toluenesulfonyl)ethoxyethyl]-5'-O-monomethoxytrityl-2',3'-O-isopropylideneinosine (1232139-79-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1039/b9nj00595a

Reference yield:

5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine (239080-20-7) → N1-[(5-para-toluenesulfonyl)ethoxyethyl]-5'-O-monomethoxytrityl-2',3'-O-isopropylideneinosine (1232139-79-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2: N,N-dimethyl-formamide / 8 h / 50 °C

3: dmap; triethylamine / dichloromethane / 8 h / 20 °C

With dmap; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/b9nj00595a

Reference yield:

N-1-(2,4-dinitrophenyl)-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine (239080-21-8) → N1-[(5-para-toluenesulfonyl)ethoxyethyl]-5'-O-monomethoxytrityl-2',3'-O-isopropylideneinosine (1232139-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 8 h / 50 °C

2: dmap; triethylamine / dichloromethane / 8 h / 20 °C

With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/b9nj00595a

upstream raw materials:

N1-[(5-hydroxyl)ethoxyethyl]-5'-O-monomethoxytrityl-2',3'-O-isopropylideneinosine

p-toluenesulfonyl chloride

5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine

N-1-(2,4-dinitrophenyl)-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine

Downstream raw materials:

N1-[(5-O-pyrophosphate)ethoxyethyl]-5'-O-monomethoxytrityl-2',3'-O-isopropylideneinosine