N-1-(2,4-dinitrophenyl)-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine

Base Information

• Chemical Name: N-1-(2,4-dinitrophenyl)-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine
• CAS No.: 239080-21-8
• Molecular Formula: C₃₉H₃₄N₆O₁₀
• Molecular Weight: 746.733
• Mol file: 239080-21-8.mol

Synonyms:N-1-(2,4-dinitrophenyl)-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine

Chemical Property of N-1-(2,4-dinitrophenyl)-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-1-(2,4-dinitrophenyl)-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine

There total 3 articles about N-1-(2,4-dinitrophenyl)-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-chloro-2,4-dinitro-benzene (97-00-7) + 5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine (239080-20-7) → N-1-(2,4-dinitrophenyl)-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine (239080-21-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2.5h;

DOI:10.1021/jo0000877

Reference yield:

2',3'-O-isopropylideneinosine (2140-11-6) → N-1-(2,4-dinitrophenyl)-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine (239080-21-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / pyridine / 40 h / 20 °C

2: 90 percent / K₂CO₃ / dimethylformamide / 2.5 h / 80 °C

With potassium carbonate; In pyridine; N,N-dimethyl-formamide; 1: Alkylation / 2: Substitution;

DOI:10.1021/jo0000877

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → N-1-(2,4-dinitrophenyl)-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine (239080-21-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / pyridine / 40 h / 20 °C

2: 90 percent / K₂CO₃ / dimethylformamide / 2.5 h / 80 °C

With potassium carbonate; In pyridine; N,N-dimethyl-formamide; 1: Alkylation / 2: Substitution;

DOI:10.1021/jo0000877

upstream raw materials:

1-chloro-2,4-dinitro-benzene

5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine

2',3'-O-isopropylideneinosine

mono-4-methoxytrityl chloride

Downstream raw materials:

C₄₈H₅₁N₇O₁₃

5-[[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-(hydroxymethyl)cyclopentyl]aminomethyleneamino]-1-[5-O-(monomethoxytrityl)-2,3-O-(isopropylidene)-β-D-ribofuranosyl]imidazole-4-(N-2,4-dinitrophenyl)carboxamide

C₅₄H₆₅N₇O₁₃Si

C₅₄H₆₄BrN₇O₁₃Si