3-(5-(4-(1H-benzo[d]imidazol-2-yl)-3-fluorophenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

Base Information

Chemical Name:3-(5-(4-(1H-benzo[d]imidazol-2-yl)-3-fluorophenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid
CAS No.:1438244-65-5
Molecular Formula:C₂₂H₁₇FN₄O₃
Molecular Weight:404.4
Hs Code.:

Synonyms:3-(5-(4-(1H-benzo[d]imidazol-2-yl)-3-fluorophenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

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Chemical Property of 3-(5-(4-(1H-benzo[d]imidazol-2-yl)-3-fluorophenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

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Technology Process of 3-(5-(4-(1H-benzo[d]imidazol-2-yl)-3-fluorophenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

There total 4 articles about 3-(5-(4-(1H-benzo[d]imidazol-2-yl)-3-fluorophenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1438250-36-2
ethyl 3-(5-(4-(1H-benzo[d]imidazol-2-yl)-3-fluorophenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate

: 1438244-65-5
3-(5-(4-(1H-benzo[d]imidazol-2-yl)-3-fluorophenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

Guidance literature:: ethyl 3-(5-(4-(1H-benzo[d]imidazol-2-yl)-3-fluorophenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=4;

Reference yield:

: 17205-02-6
ethyl trans-3-hydroxycyclobutanecarboxylate

: 1438244-65-5
3-(5-(4-(1H-benzo[d]imidazol-2-yl)-3-fluorophenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 50 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: Oxone / water; N,N-dimethyl-formamide / 1.5 h / 20 °C

4.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

4.2: pH 4

With Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; caesium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1438249-76-3
ethyl 3-(5-(3-fluoro-4-formylphenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate

: 1438244-65-5
3-(5-(4-(1H-benzo[d]imidazol-2-yl)-3-fluorophenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: Oxone / water; N,N-dimethyl-formamide / 1.5 h / 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

2.2: pH 4

With Oxone; water; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;