N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalanine

Base Information

Chemical Name:N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalanine
CAS No.:1192471-43-4
Molecular Formula:C₁₇H₁₈N₄O₅S
Molecular Weight:390.42
Hs Code.:

Synonyms:N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalanine

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Chemical Property of N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalanine

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Technology Process of N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalanine

There total 3 articles about N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1192471-36-5
cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalaninate

: 1192471-43-4
N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalanine

Guidance literature:: cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalaninate; With water; lithium hydroxide; In tetrahydrofuran; at 40 ℃;

With hydrogenchloride; In water; pH=5;

Reference yield:

: 25487-66-5
3-Carboxyphenylboronic acid

: 1192471-43-4
N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalanine

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.33 h / 0 °C

1.2: 4 h / 20 °C

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / Reflux; Inert atmosphere

3.1: water; lithium hydroxide / tetrahydrofuran / 40 °C

3.2: pH 5

With water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 2.1: Suzuki Coupling;

Reference yield:

: 1192471-48-9
cyclopentyl N-[3-(dihydroxyboryl)benzoyl]-2-methylalaninate

: 1192471-43-4
N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalanine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / Reflux; Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran / 40 °C

2.2: pH 5

With water; sodium hydrogencarbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: Suzuki Coupling;