cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalaninate

Base Information

Chemical Name:cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalaninate
CAS No.:1192471-36-5
Molecular Formula:C₂₂H₂₆N₄O₅S
Molecular Weight:458.538
Hs Code.:

Synonyms:cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalaninate

Suppliers and Price of cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalaninate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalaninate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalaninate

There total 5 articles about cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 354812-10-5
2-[(aminocarbonyl)amino]-5-bromo-3-thiophenecarboxamide

: 1192471-48-9
cyclopentyl N-[3-(dihydroxyboryl)benzoyl]-2-methylalaninate

: 1192471-36-5
cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalaninate

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 16h; Reflux; Inert atmosphere;

Reference yield:

: cyclopentyl 2-amino-2-methylpropanoate hydrochloride

: 1192471-36-5
cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.33 h / 0 °C

1.2: 4 h / 20 °C

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / Reflux; Inert atmosphere

With sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; 2.1: Suzuki Coupling;

Reference yield:

: 96-41-3
Cyclopentanol

: 1192471-36-5
cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzoyl}-2-methylalaninate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

2.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 24 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.33 h / 0 °C

3.2: 4 h / 20 °C

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / Reflux; Inert atmosphere

With hydrogenchloride; dmap; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; 4.1: Suzuki Coupling;