(2S,4S,5S,6S)-5-hydroxy-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptan-3-one

Base Information

Chemical Name:(2S,4S,5S,6S)-5-hydroxy-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptan-3-one
CAS No.:548437-25-8
Molecular Formula:C₂₇H₄₈O₅Si
Molecular Weight:480.761
Hs Code.:

Synonyms:(2S,4S,5S,6S)-5-hydroxy-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptan-3-one

Suppliers and Price of (2S,4S,5S,6S)-5-hydroxy-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptan-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2S,4S,5S,6S)-5-hydroxy-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptan-3-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4S,5S,6S)-5-hydroxy-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptan-3-one

There total 1 articles about (2S,4S,5S,6S)-5-hydroxy-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 182193-69-7
(S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one

: (S)-2-methyl-3-(triisopropylsilyloxy)propanal

: 548437-25-8
(2S,4S,5S,6S)-5-hydroxy-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptan-3-one

: (2S,4S,5R,6S)-5-hydroxy-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptan-3-one

Guidance literature:: With dicyclohexylboron chloride; triethylamine; In diethyl ether; at -78 ℃;
DOI:10.1021/ol034558y

Reference yield: 90.0%

: 548437-25-8
(2S,4S,5S,6S)-5-hydroxy-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptan-3-one

: 548437-26-9
(2S,3S,4R,5S,6S)-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptane-3,5-diol

Guidance literature:: With acetic acid; tetramethylammonium triacetoxyborohydride; In acetonitrile;
DOI:10.1021/ol034558y

Reference yield:

: 548437-25-8
(2S,4S,5S,6S)-5-hydroxy-1-(p-methoxybenzyloxy)-7-triisopropyloxy-2,4,6-trimethylheptan-3-one

: (2R,3R,4S)-3-Methoxy-4-[(2S,4R,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentanal

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / Me₄NBH(OAc)3; acetic acid / acetonitrile

2: DDQ; molecular sieves 4 Angstroem / CH₂Cl₂

3: NaH / tetrahydrofuran

4: tetrabutylammonium fluoride / tetrahydrofuran

5: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂

With 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ol034558y