Ethyl 3-<4-Azido-6-(carboethoxy)-5-methylpyrimidin-2-yl>-3-(benzylamino)propionate

Base Information

Chemical Name:Ethyl 3-<4-Azido-6-(carboethoxy)-5-methylpyrimidin-2-yl>-3-(benzylamino)propionate
CAS No.:76480-77-8
Molecular Formula:C₂₀H₂₄N₆O₄
Molecular Weight:412.448
Hs Code.:

Synonyms:Ethyl 3-<4-Azido-6-(carboethoxy)-5-methylpyrimidin-2-yl>-3-(benzylamino)propionate

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Chemical Property of Ethyl 3-<4-Azido-6-(carboethoxy)-5-methylpyrimidin-2-yl>-3-(benzylamino)propionate

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Technology Process of Ethyl 3-<4-Azido-6-(carboethoxy)-5-methylpyrimidin-2-yl>-3-(benzylamino)propionate

There total 11 articles about Ethyl 3-<4-Azido-6-(carboethoxy)-5-methylpyrimidin-2-yl>-3-(benzylamino)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 76480-76-7
Ethyl 3-<4-Azido-6-(carboethoxy)-5-methylpyrimidin-2-yl>-3-bromopropionate

: 100-46-9
benzylamine

: 76480-77-8
Ethyl 3-<4-Azido-6-(carboethoxy)-5-methylpyrimidin-2-yl>-3-(benzylamino)propionate

Guidance literature:: With sodium hydrogencarbonate; In methanol; at 25 ℃; for 1h;
DOI:10.1021/jo00320a037

Reference yield:

: 759-65-9
diethyl oxalpropionate

: 76480-77-8
Ethyl 3-<4-Azido-6-(carboethoxy)-5-methylpyrimidin-2-yl>-3-(benzylamino)propionate

Guidance literature:: Multi-step reaction with 11 steps

1: 43 percent / KOH / ethanol / Heating

2: 65 percent / conc. HCl / H₂O

3: 67 percent / pyridine / 44 h / 85 °C

4: Ac₂O / pyridine / Ambient temperature

5: 95percent H₂SO₄ / 18 h / 70 °C

6: 92 percent / 5.5 h / Heating

7: 100 percent / H₂ / 1percent Pd/C / ethyl acetate; ethanol / 12 h / 1551.4 Torr

8: 96 percent / Phosphorous oxychloride / 0.5 h / Heating

9: 86 percent / Sodium azide / dimethylformamide / 18 h / 25 °C

10: 100 percent / Dioxane dibromide / CCl₄ / 1 h / Heating

11: 41 percent / NaHCO₃ / methanol / 1 h / 25 °C

With hydrogenchloride; potassium hydroxide; sodium azide; 1,4-dioxane dibromide; sulfuric acid; hydrogen; acetic anhydride; sodium hydrogencarbonate; trichlorophosphate; palladium on activated charcoal; In pyridine; methanol; tetrachloromethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00320a037

Reference yield:

: 39875-10-0
2,5-Dimethyl-4-oxopyrimidine-6-carboxylic Acid

: 76480-77-8
Ethyl 3-<4-Azido-6-(carboethoxy)-5-methylpyrimidin-2-yl>-3-(benzylamino)propionate

Guidance literature:: Multi-step reaction with 9 steps

1: 67 percent / pyridine / 44 h / 85 °C

2: Ac₂O / pyridine / Ambient temperature

3: 95percent H₂SO₄ / 18 h / 70 °C

4: 92 percent / 5.5 h / Heating

5: 100 percent / H₂ / 1percent Pd/C / ethyl acetate; ethanol / 12 h / 1551.4 Torr

6: 96 percent / Phosphorous oxychloride / 0.5 h / Heating

7: 86 percent / Sodium azide / dimethylformamide / 18 h / 25 °C

8: 100 percent / Dioxane dibromide / CCl₄ / 1 h / Heating

9: 41 percent / NaHCO₃ / methanol / 1 h / 25 °C

With sodium azide; 1,4-dioxane dibromide; sulfuric acid; hydrogen; acetic anhydride; sodium hydrogencarbonate; trichlorophosphate; palladium on activated charcoal; In pyridine; methanol; tetrachloromethane; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00320a037