furo[2,3-c]pyridin-2-carboxylic acid [5-(3-trifluoromethylbenzenesulfonyl)pyridin-2-ylmethyl]amide

Base Information

Chemical Name:furo[2,3-c]pyridin-2-carboxylic acid [5-(3-trifluoromethylbenzenesulfonyl)pyridin-2-ylmethyl]amide
CAS No.:1454250-90-8
Molecular Formula:C₂₁H₁₄F₃N₃O₄S
Molecular Weight:461.421
Hs Code.:

Synonyms:furo[2,3-c]pyridin-2-carboxylic acid [5-(3-trifluoromethylbenzenesulfonyl)pyridin-2-ylmethyl]amide

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Chemical Property of furo[2,3-c]pyridin-2-carboxylic acid [5-(3-trifluoromethylbenzenesulfonyl)pyridin-2-ylmethyl]amide

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Technology Process of furo[2,3-c]pyridin-2-carboxylic acid [5-(3-trifluoromethylbenzenesulfonyl)pyridin-2-ylmethyl]amide

There total 11 articles about furo[2,3-c]pyridin-2-carboxylic acid [5-(3-trifluoromethylbenzenesulfonyl)pyridin-2-ylmethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1374864-85-3
(5-[[3-(trifluoromethyl)benzene]sulfonyl]pyridin-2-yl)methanamine

: 112372-15-3
furo<2,3-c>pyridine-2-carboxylic acid

: 1454250-90-8
furo[2,3-c]pyridin-2-carboxylic acid [5-(3-trifluoromethylbenzenesulfonyl)pyridin-2-ylmethyl]amide

Guidance literature:: furo<2,3-c>pyridine-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(5-[[3-(trifluoromethyl)benzene]sulfonyl]pyridin-2-yl)methanamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1454252-66-4
5-[[3-(trifluoromethyl)phenyl]sulfanyl]pyridin-2-carbonitrile

: 1454250-90-8
furo[2,3-c]pyridin-2-carboxylic acid [5-(3-trifluoromethylbenzenesulfonyl)pyridin-2-ylmethyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C

2.1: hydrazine hydrate / methanol / 0.17 h / 0 - 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 20 °C

With benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1454252-67-5
5-(3-(trifluoromethyl)phenylsulfonyl)picolinonitrile

: 1454250-90-8
furo[2,3-c]pyridin-2-carboxylic acid [5-(3-trifluoromethylbenzenesulfonyl)pyridin-2-ylmethyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / methanol / 0.17 h / 0 - 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 20 °C

With benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; N,N-dimethyl-formamide;