(3RS,4S)-3-hydroxy-2-hydroxymethyl-6-methyl-4-tritylamino-1,6-heptadiene

Base Information

Chemical Name:(3RS,4S)-3-hydroxy-2-hydroxymethyl-6-methyl-4-tritylamino-1,6-heptadiene
CAS No.:141632-06-6
Molecular Formula:C₂₈H₃₁NO₂
Molecular Weight:413.56
Hs Code.:

Synonyms:(3RS,4S)-3-hydroxy-2-hydroxymethyl-6-methyl-4-tritylamino-1,6-heptadiene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3RS,4S)-3-hydroxy-2-hydroxymethyl-6-methyl-4-tritylamino-1,6-heptadiene

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Technology Process of (3RS,4S)-3-hydroxy-2-hydroxymethyl-6-methyl-4-tritylamino-1,6-heptadiene

There total 7 articles about (3RS,4S)-3-hydroxy-2-hydroxymethyl-6-methyl-4-tritylamino-1,6-heptadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 598-19-6
2-bromoallyl alcohol

: 141632-05-5
(S)-4-methyl-2-tritylamino-4-pentenal

: 141632-06-6
(3RS,4S)-3-hydroxy-2-hydroxymethyl-6-methyl-4-tritylamino-1,6-heptadiene

Guidance literature:: With n-butyllithium; In diethyl ether; pentane; for 3h;
DOI:10.1055/s-1994-25464

Reference yield:

: 87325-65-3,88547-24-4
(R,S)-2-acetamido-4-methyl-4-pentenoic acid

: 141632-06-6
(3RS,4S)-3-hydroxy-2-hydroxymethyl-6-methyl-4-tritylamino-1,6-heptadiene

Guidance literature:: Multi-step reaction with 5 steps

1: 42 percent / phenol red, 25percent NH₄OH, acylase (from pork kidney), pH 7.0-7.2 / H₂O / 24 h / 33 °C

2: NaOH, LiAlH₄ / tetrahydrofuran / 2 h / Heating

3: 85 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

4: 98 percent / (COCl)2, DMSO, Et₃N / CH₂Cl₂

5: 73 percent / 1.6 M BuLi / diethyl ether; pentane / 3 h

With ammonium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; acylase (from pork kidney); phenol red; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; pentane;
DOI:10.1055/s-1994-25464

Reference yield:

: 87392-13-0,905929-81-9
(2S)-2-amino-4-methylpent-4-enoic acid

: 141632-06-6
(3RS,4S)-3-hydroxy-2-hydroxymethyl-6-methyl-4-tritylamino-1,6-heptadiene

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH, LiAlH₄ / tetrahydrofuran / 2 h / Heating

2: 85 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

3: 98 percent / (COCl)2, DMSO, Et₃N / CH₂Cl₂

4: 73 percent / 1.6 M BuLi / diethyl ether; pentane / 3 h

With sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; pentane;
DOI:10.1055/s-1994-25464