4-(5-bromo-pyrimidin-2-yl)-piperazine-1-carboxylic acid (4-benzyloxy-phenyl)-amide

Base Information

• Chemical Name: 4-(5-bromo-pyrimidin-2-yl)-piperazine-1-carboxylic acid (4-benzyloxy-phenyl)-amide
• CAS No.: 1215855-10-9
• Molecular Formula: C₂₂H₂₂BrN₅O₂
• Molecular Weight: 468.353
• Mol file: 1215855-10-9.mol

Synonyms:4-(5-bromo-pyrimidin-2-yl)-piperazine-1-carboxylic acid (4-benzyloxy-phenyl)-amide

Chemical Property of 4-(5-bromo-pyrimidin-2-yl)-piperazine-1-carboxylic acid (4-benzyloxy-phenyl)-amide

Chemical Property:

Purity/Quality:

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Technology Process of 4-(5-bromo-pyrimidin-2-yl)-piperazine-1-carboxylic acid (4-benzyloxy-phenyl)-amide

There total 1 articles about 4-(5-bromo-pyrimidin-2-yl)-piperazine-1-carboxylic acid (4-benzyloxy-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

bis(trichloromethyl) carbonate (32315-10-9) + 4-benzyloxyaniline hydrochloride (51388-20-6) + 1-(5-bromopyrimidin-2-yl)piperazine (99931-82-5) → 4-(5-bromo-pyrimidin-2-yl)-piperazine-1-carboxylic acid (4-benzyloxy-phenyl)-amide (1215855-10-9)

Guidance literature:

bis(trichloromethyl) carbonate; 4-benzyloxyaniline hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

1-(5-bromopyrimidin-2-yl)piperazine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 16.0%

4-(5-bromo-pyrimidin-2-yl)-piperazine-1-carboxylic acid (4-benzyloxy-phenyl)-amide (1215855-10-9) + allyl alcohol (107-18-6) → 4-[5-(3-hydroxy-propyl)-pyrimidin-2-yl]-piperazine-1-carboxylic acid (4-benzyloxyphenyl)-amide (1215855-11-0)

Guidance literature:

allyl alcohol; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 0 - 20 ℃;

4-(5-bromo-pyrimidin-2-yl)-piperazine-1-carboxylic acid (4-benzyloxy-phenyl)-amide; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 65 ℃;

upstream raw materials:

bis(trichloromethyl) carbonate

4-benzyloxyaniline hydrochloride

1-(5-bromopyrimidin-2-yl)piperazine

Downstream raw materials:

4-[5-(3-hydroxy-propyl)-pyrimidin-2-yl]-piperazine-1-carboxylic acid (4-benzyloxyphenyl)-amide