(2S)-methoxyphenyl acetic acid (1R)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester

Base Information

Chemical Name:(2S)-methoxyphenyl acetic acid (1R)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester
CAS No.:864961-07-9
Molecular Formula:C₂₃H₂₈FNO₅
Molecular Weight:417.477
Hs Code.:

Synonyms:(2S)-methoxyphenyl acetic acid (1R)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester

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Chemical Property of (2S)-methoxyphenyl acetic acid (1R)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester

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Technology Process of (2S)-methoxyphenyl acetic acid (1R)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester

There total 5 articles about (2S)-methoxyphenyl acetic acid (1R)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864961-02-4
[2-(4-fluorophenyl)-2-hydroxyethyl]methylcarbamic acid t-butyl ester

: 26164-26-1
(S)-2-methoxy-2-phenylacetic acid

: 864961-07-9
(2S)-methoxyphenyl acetic acid (1R)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester

: 864961-06-8
(2S)-methoxyphenyl acetic acid (1S)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 3.5h;

Reference yield:

: 131326-99-3
2-(Benzyl-methyl-amino)-1-(4-fluorophenyl)-ethanone

: 864961-07-9
(2S)-methoxyphenyl acetic acid (1R)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

2: palladium 10% on activated carbon / methanol; ethyl acetate / 3 h / 50 °C

3: sodium hydrogencarbonate / tetrahydrofuran; water / 1.5 h / 20 °C

4: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3.5 h / 0 - 20 °C

With dmap; sodium tetrahydroborate; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 133962-00-2
1-(4-fluorophenyl)-2-<(N-benzyl-N-methyl)amino>ethanol

: 864961-07-9
(2S)-methoxyphenyl acetic acid (1R)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon / methanol; ethyl acetate / 3 h / 50 °C

2: sodium hydrogencarbonate / tetrahydrofuran; water / 1.5 h / 20 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3.5 h / 0 - 20 °C

With dmap; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;