2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-difluoromethoxyphenyl)-1H-benzimidazole

Base Information

Chemical Name:2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-difluoromethoxyphenyl)-1H-benzimidazole
CAS No.:1392516-97-0
Molecular Formula:C₂₂H₂₂F₂N₄O
Molecular Weight:396.44
Hs Code.:

Synonyms:2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-difluoromethoxyphenyl)-1H-benzimidazole

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Chemical Property of 2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-difluoromethoxyphenyl)-1H-benzimidazole

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Technology Process of 2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-difluoromethoxyphenyl)-1H-benzimidazole

There total 2 articles about 2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-difluoromethoxyphenyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392516-96-9
3-tert-Butyl-1-methyl-1H-pyrazole-5-carboxylic acid (3-nitro-2'-difluoromethoxy-biphenyl-4-yl)-amide

: 1392516-97-0
2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-difluoromethoxyphenyl)-1H-benzimidazole

Guidance literature:: 3-tert-Butyl-1-methyl-1H-pyrazole-5-carboxylic acid (3-nitro-2'-difluoromethoxy-biphenyl-4-yl)-amide; With water; iron; ammonium chloride; In ethanol; at 80 ℃; for 12h;

With camphor-10-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 12h;

With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; Saturated solution;

Reference yield:

: 133261-10-6
5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1392516-97-0
2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-difluoromethoxyphenyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / methanol / 72 h / 20 °C

1.2: pH 2

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; sodium hydride; pyridine / mineral oil / 20 °C

3.1: water; ammonium chloride; iron / ethanol / 12 h / 80 °C

3.2: 12 h / 100 °C

3.3: 20 °C / Saturated solution

With pyridine; water; iron; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; sodium hydroxide; In methanol; ethanol; mineral oil;