N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methylbenzamide

Base Information

Chemical Name:N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methylbenzamide
CAS No.:896739-23-4
Molecular Formula:C₂₆H₂₀FN₅O
Molecular Weight:437.476
Hs Code.:

Synonyms:N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methylbenzamide

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Chemical Property of N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methylbenzamide

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Technology Process of N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methylbenzamide

There total 7 articles about N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 896737-63-6
4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-amine

: 933-88-0
ortho-toluoyl chloride

: 896739-23-4
N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methylbenzamide

Guidance literature:: 4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-amine; ortho-toluoyl chloride; With triethylamine; In dichloromethane; at 20 ℃;

With ammonia; In ethanol; dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2017.12.031

Reference yield:

: 365428-32-6
2-(2-aminopyridin-4-yl)-2-bromo-1-(4-fluoro-3-methylphenyl)ethanone hydrobromide

: 896739-23-4
N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 80 °C

2.1: palladium 10% on activated carbon; hydrogen; triethylamine / N,N-dimethyl-formamide / 20 °C / 750.08 Torr

3.1: triethylamine / dichloromethane / 20 °C

3.2: 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2017.12.031

Reference yield:

: 896737-59-0
4-[6-chloro-2-(4-fluoro-3-methylphenyl)imidazo[1, 2-b]pyridazin-3-yl]pyridin-2-amine

: 896739-23-4
N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen; triethylamine / N,N-dimethyl-formamide / 20 °C / 750.08 Torr

2.1: triethylamine / dichloromethane / 20 °C

2.2: 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2017.12.031