N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>isoleucine

Base Information

Chemical Name:N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>isoleucine
CAS No.:150115-35-8
Molecular Formula:C₃₃H₄₂N₂O₄S
Molecular Weight:562.773
Hs Code.:

Synonyms:N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>isoleucine

Suppliers and Price of N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>isoleucine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>isoleucine

Chemical Property:

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Technology Process of N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>isoleucine

There total 1 articles about N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>isoleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 73-32-5,959215-79-3,18875-42-8
L-isoleucine

: 149910-63-4
N-α-(tert-butoxycarbonyl)-S-(triphenylmethyl)-L-cysteinal

: 150115-35-8
N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>isoleucine

Guidance literature:: With 3 A molecular sieve; sodium cyanoborohydride; In ethanol; Ambient temperature;
DOI:10.1021/jm00020a010

Reference yield: 76.0%

: 62-53-3
aniline

: 150115-35-8
N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>isoleucine

: 157325-00-3
N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>-N-phenylisoleucine amide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 20h; Ambient temperature;
DOI:10.1021/jm00020a010

Reference yield:

: 150115-35-8
N-<2(R)-<(tert-butoxycarbonyl)amino>-3-<(triphenylmethyl)thio>propyl>isoleucine

: N-[2(R)-Amino-3-mercaptopropyl]-L-isoleucine-benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide, 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine, 2.) diisopropylethylamine / 1.) EtOAc, CHCl₃, RT, 0.5 h, 2.) EtOAc, CHCl₃, 48 h

2: TFA, triethylsilane / CH₂Cl₂ / 3 h / Ambient temperature

With triethylsilane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00020a010