2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzonitrile

Base Information

Chemical Name:2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzonitrile
CAS No.:1192454-70-8
Molecular Formula:C₁₉H₁₂F₂IN₃O
Molecular Weight:463.225
Hs Code.:

Synonyms:2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzonitrile

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Chemical Property of 2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzonitrile

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Technology Process of 2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzonitrile

There total 3 articles about 2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1192454-69-5
[3-(3-tert-butoxycarbonylamino-phenoxy)-2-cyano-5-fluoro-phenyl]-(2-fluoro-4-iodo-phenyl)-carbamic acid tert-butyl ester

: 1084332-21-7
2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzamide

: 1192454-70-8
2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzonitrile

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 1084333-50-5
2-(2-cyano-3,5-difluoro-phenyl)-(2-fluoro-4-iodo-phenyl)-carbamic acid tert-butyl ester

: 19962-06-2
tert-butyl 3-hydroxyphenylcarbamate

: 1084332-21-7
2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzamide

: 1192454-70-8
2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzonitrile

: C₁₉H₁₂F₂IN₃O

: C₁₉H₁₄F₂IN₃O₂

Guidance literature:: 2-(2-cyano-3,5-difluoro-phenyl)-(2-fluoro-4-iodo-phenyl)-carbamic acid tert-butyl ester; tert-butyl 3-hydroxyphenylcarbamate; With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 16h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 1084333-49-2
2,4-difluoro-6-(2-fluoro-4-iodo-phenylamino)-benzonitrile

: 1192454-70-8
2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

3: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; dmap; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;