(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-naphthalen-2-yl-tetrahydro-furan-3-ol

Base Information

Chemical Name:(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-naphthalen-2-yl-tetrahydro-furan-3-ol
CAS No.:180611-71-6
Molecular Formula:C₃₆H₃₄O₅
Molecular Weight:546.663
Hs Code.:

Synonyms:(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-naphthalen-2-yl-tetrahydro-furan-3-ol

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Chemical Property of (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-naphthalen-2-yl-tetrahydro-furan-3-ol

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Technology Process of (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-naphthalen-2-yl-tetrahydro-furan-3-ol

There total 8 articles about (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-naphthalen-2-yl-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 180611-60-3
1,2-dideoxy-β-1-(2-naphthyl)-D-ribofuranose

: 180611-71-6
(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-naphthalen-2-yl-tetrahydro-furan-3-ol

Guidance literature:: With pyridine; dmap; In dichloromethane; at 23 ℃; for 8h;
DOI:10.1021/ja9612763

Reference yield: 66.0%

: 180611-71-6
(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-naphthalen-2-yl-tetrahydro-furan-3-ol

Guidance literature:

Reference yield:

: 21473-01-8
2-naphthalenylmagnesium bromide

: 180611-71-6
(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-naphthalen-2-yl-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuI / tetrahydrofuran / 0.08 h / 0 °C

1.2: tetrahydrofuran / 0.5 h / 25 °C

1.3: NaOMe; MeOH / 4 h

2.1: 4-(dimethylamino)pyridine; iPr₂NEt; pyridine / CH₂Cl₂ / 8 h

With pyridine; dmap; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.200219972