(2R,3R)-N-((3S)-1-(3-cyanophenyl)-6-(difluoromethyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-phenyl-2-(3,3,3-trifluoropropyl)succinamide

Base Information

Chemical Name:(2R,3R)-N-((3S)-1-(3-cyanophenyl)-6-(difluoromethyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-phenyl-2-(3,3,3-trifluoropropyl)succinamide
CAS No.:1584149-67-6
Molecular Formula:C₃₀H₂₆F₅N₅O₃
Molecular Weight:599.56
Hs Code.:

Synonyms:(2R,3R)-N-((3S)-1-(3-cyanophenyl)-6-(difluoromethyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-phenyl-2-(3,3,3-trifluoropropyl)succinamide

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Chemical Property of (2R,3R)-N-((3S)-1-(3-cyanophenyl)-6-(difluoromethyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-phenyl-2-(3,3,3-trifluoropropyl)succinamide

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Technology Process of (2R,3R)-N-((3S)-1-(3-cyanophenyl)-6-(difluoromethyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-phenyl-2-(3,3,3-trifluoropropyl)succinamide

There total 11 articles about (2R,3R)-N-((3S)-1-(3-cyanophenyl)-6-(difluoromethyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-phenyl-2-(3,3,3-trifluoropropyl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1584150-55-9
(2R,3R)-3-(((S)-1-(3-cyanophenyl)-6-(difluoromethyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-phenylhexanoic acid

: 1584149-67-6
(2R,3R)-N-((3S)-1-(3-cyanophenyl)-6-(difluoromethyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-phenyl-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 2h;

Reference yield:

: 1581734-81-7
benzyl (2R)-5,5,5-trifluoro-2-{[(trifluoromethyl)sulfonyl]oxy}pentanoate

: 1584149-67-6
(2R,3R)-N-((3S)-1-(3-cyanophenyl)-6-(difluoromethyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-phenyl-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0.83 h / -78 - 20 °C

1.2: 1.17 h / -78 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 20 °C

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

5.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ammonia / tetrahydrofuran; isopropyl alcohol / 2 h / 20 °C

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; ammonia; hydrogen; potassium hexamethylsilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; isopropyl alcohol; toluene;

Reference yield:

: 1581734-83-9
(R)-2-((R)-2-(tert-butoxy)-2-oxo-1-phenylethyl)-5,5,5-trifluoropentanoic acid

: 1584149-67-6
(2R,3R)-N-((3S)-1-(3-cyanophenyl)-6-(difluoromethyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-phenyl-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ammonia / tetrahydrofuran; isopropyl alcohol / 2 h / 20 °C

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; isopropyl alcohol;