(1R,2R)-2-[2'-hydroxy-1'-(R)-phenylethylcarbamoyl]-cyclopentane-1-carboxylic acid

Base Information

Chemical Name:(1R,2R)-2-[2'-hydroxy-1'-(R)-phenylethylcarbamoyl]-cyclopentane-1-carboxylic acid
CAS No.:889888-79-3
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:

Synonyms:(1R,2R)-2-[2'-hydroxy-1'-(R)-phenylethylcarbamoyl]-cyclopentane-1-carboxylic acid

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Chemical Property of (1R,2R)-2-[2'-hydroxy-1'-(R)-phenylethylcarbamoyl]-cyclopentane-1-carboxylic acid

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Technology Process of (1R,2R)-2-[2'-hydroxy-1'-(R)-phenylethylcarbamoyl]-cyclopentane-1-carboxylic acid

There total 5 articles about (1R,2R)-2-[2'-hydroxy-1'-(R)-phenylethylcarbamoyl]-cyclopentane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 889888-78-2
(1R,2R)-2-[2'-hydroxy-1'-(R)-phenylethylcarbamoyl]-cyclopentane-1-carboxylic acid methyl ester

: 889888-79-3
(1R,2R)-2-[2'-hydroxy-1'-(R)-phenylethylcarbamoyl]-cyclopentane-1-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 4h;
DOI:10.1016/j.tetasy.2005.12.036

Reference yield:

: 35878-28-5,743438-34-8
cyclopentane-cis-1,2-dicarboxylic acid anhydride

: 889888-79-3
(1R,2R)-2-[2'-hydroxy-1'-(R)-phenylethylcarbamoyl]-cyclopentane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / quinidine

2.1: LDA / tetrahydrofuran / 4 h / -78 °C

2.2: 80 percent / HCl / H₂O; tetrahydrofuran

3.1: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 0 - 20 °C

4.1: 4.667 g / triethylamine / CH₂Cl₂ / 0 - 20 °C

5.1: 97 percent / sodium hydroxide / methanol / 4 h / 20 °C

With sodium hydroxide; oxalyl dichloride; triethylamine; lithium diisopropyl amide; quinidine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2005.12.036

Reference yield:

: 111138-68-2
trans-(1R,2R)-cyclopentane-1-carboxylic acid methyl ester 2-carboxylic acid

: 889888-79-3
(1R,2R)-2-[2'-hydroxy-1'-(R)-phenylethylcarbamoyl]-cyclopentane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 0 - 20 °C

2: 4.667 g / triethylamine / CH₂Cl₂ / 0 - 20 °C

3: 97 percent / sodium hydroxide / methanol / 4 h / 20 °C

With sodium hydroxide; oxalyl dichloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2005.12.036