111138-68-2

Upstream product

• 67-56-1 methanol 
• 80656-14-0 trans-1,2-cyclopentanedicarboxylic acid 
• 35878-28-5 cyclopentane-cis-1,2-dicarboxylic acid anhydride 
• 1461-96-7 cis-1,2-cyclopentanedicarboxylic acid 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 4841-91-2 dimethyl cis-1,2-cyclopentanedicarboxylate 

Downstream Products

• 277751-14-1 trans-methyl (1R,2R)-2-{4-[amino(benzyloxycarbonylimino)methyl]benzylaminocarbontl}cyclopentanecarboxylate 
• 1220117-01-0 C₈H₁₄O₃ 
• 1445589-57-0 methyl ((S)-3-methyl-1-((S)-2-(5-(4’-(2-((1R,2R)-2-((1-methyl-1H-pyrazol-3-yl)carbamoyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate 
• 1445589-59-2 methyl ((S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(2-((1R,2R)-2-(pyridin-2-ylcarbamoyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-yl)carbamate 
• 1445589-60-5 methyl ((2S)-1-((3aS,6aS)-2-(5-(4-(2-((1S,2S)-2-carbamoylcyclopentyl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)hexahydrocyclopenta[b]pyrrol-1(2H)-yl)-3-methyl-1-oxobutan-2-yl)carbamate 
• 1445590-49-7 ((1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentyl)((S)-3-(tert-butoxymethyl)morpholino)methanone 
• 1445591-92-3 (1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid 
• 1445590-41-9 ((1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone 
• 1445590-77-1 ((R)-3-methylmorpholino)((1R,2R)-2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)methanone 
• 1445591-93-4 (1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate 
• 1445591-94-5 (1R,2R)-tert-butyl 2-(5-(4'-(2-((S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylate 
• 1445590-78-2 (1R,2 R)-2-(5-(4'-(2-((S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid 
• 1445590-85-1 (1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid 
• 1445597-10-3 methyl ((S)-1-((2S,4S)-4-methoxy-2-(5-(4-(2-((1R,2R)-2-((R)-3-methylmorpholine-4-carbonyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate 

Relevant academic research and scientific papers

NOVEL HEPATITIS C VIRUS INHIBITORS

The invention provides compounds of formula (I): wherein Rings A and A' are independently 5-membered optionally substituted aromatic heterocycles; Q is C(=O)NR1R1' or formula U is C(R4)2, O, S, S(=O)2, C(R4)2C(R4)2, CH2O, OCH2, CH2S, SCH2, CH2S(=O)2, S(=O)CH2 or C=C(Ru )2; X is CH2, CHR12, CR12R12, O, S, S(=O)2 or NRx; m is 0, 1, 2 or 3; n is 0, 1, 2 or 3; the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.

Total synthesis of (+)-brefeldin C, (+)-nor-Me brefeldin A and (+)-4-epi-nor-Me brefeldin A

A total synthesis of (+)-brefeldin C (BFC) and two brefeldin A (BFA) analogues - (+)-nor-Me BFA and (+)-4-epi-nor-Me BFA - has been developed. Key features of the syntheses include desymmetrization of meso anhydrides, a Carreira reaction to control the ab