5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazol-2-one

Base Information

Chemical Name:5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazol-2-one
CAS No.:1433902-27-2
Molecular Formula:C₂₂H₁₉ClN₄O₂
Molecular Weight:406.871
Hs Code.:

Synonyms:5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazol-2-one

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Chemical Property of 5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazol-2-one

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Technology Process of 5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazol-2-one

There total 5 articles about 5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1433903-59-3
6-chloro-4-phenyl-2-piperidin-1-yl-quinoline-3-carboxylic acid hydrazide

: 530-62-1
1,1'-carbonyldiimidazole

: 1433902-27-2
5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazol-2-one

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2016.08.071

Reference yield:

: 284663-87-2
6-chloro-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carboxylic acid methyl ester

: 1433902-27-2
5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide / ethanol / 72 h / 50 °C / Sealed tube

2.1: trichlorophosphate / 3 h / 120 °C

2.2: 4 h / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 0.33 h / 120 °C / Microwave irradiation

4.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

With triethylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 94205-21-7
6-chloro-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carboxylic acid

: 1433902-27-2
5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 3 h / 120 °C

1.2: 4 h / 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 0.33 h / 120 °C / Microwave irradiation

3.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

With triethylamine; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;