N^α-dipicolinoyl-bis-[L-valyl-L-phenylalanine methyl ester]

Base Information

• Chemical Name: N^α-dipicolinoyl-bis-[L-valyl-L-phenylalanine methyl ester]
• CAS No.: 947406-12-4
• Molecular Formula: C₃₇H₄₅N₅O₈
• Molecular Weight: 687.793
• Mol file: 947406-12-4.mol

Synonyms:N^α-dipicolinoyl-bis-[L-valyl-L-phenylalanine methyl ester]

Chemical Property of N^α-dipicolinoyl-bis-[L-valyl-L-phenylalanine methyl ester]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-dipicolinoyl-bis-[L-valyl-L-phenylalanine methyl ester]

There total 1 articles about N^α-dipicolinoyl-bis-[L-valyl-L-phenylalanine methyl ester] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) + N,N'-bis<(1S)-1-carboxy-2-methylpropyl>-2,6-bis(aminocarbonyl)pyridine (96844-89-2) → Nα-dipicolinoyl-bis-[L-valyl-L-phenylalanine methyl ester] (947406-12-4)

Guidance literature:

N,N'-bis<(1S)-1-carboxy-2-methylpropyl>-2,6-bis(aminocarbonyl)pyridine; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at -20 ℃; for 0.166667h;

methyl (2S)-2-amino-3-phenylpropanoate; In dichloromethane; at -20 - 20 ℃; Further stages.;

DOI:10.1002/ardp.200600187

Reference yield: 72.0%

Nα-dipicolinoyl-bis-[L-valyl-L-phenylalanine methyl ester] (947406-12-4) → Nα-dipicolinoyl-bis-[L-valyl-L-phenylalanine] (947406-16-8)

Guidance literature:

With sodium hydroxide; In methanol; at -5 - 20 ℃;

DOI:10.1002/ardp.200600187

Reference yield: 70.0%

Nα-dipicolinoyl-bis-[L-valyl-L-phenylalanine methyl ester] (947406-12-4) → Nα-dipicolinoyl-bis-[L-valyl-L-phenylalanine hydrazide] (947406-13-5)

Guidance literature:

With hydrazine hydrate; In methanol; for 5h; Heating;

DOI:10.1002/ardp.200600187

upstream raw materials:

methyl (2S)-2-amino-3-phenylpropanoate

N,N'-bis<(1S)-1-carboxy-2-methylpropyl>-2,6-bis(aminocarbonyl)pyridine

Downstream raw materials:

N^α-dipicolinoyl-bis-[L-valyl-L-phenylalanine]

N^α-dipicolinoyl-bis-[L-valyl-L-phenylalanine hydrazide]