(7R,8S,10S)-10-Benzyloxy-7-(tert-butyldimethylsilyloxymethyl)-8-dimethyl(phenyl)silylhenicosane

Base Information

Chemical Name:(7R,8S,10S)-10-Benzyloxy-7-(tert-butyldimethylsilyloxymethyl)-8-dimethyl(phenyl)silylhenicosane
CAS No.:130645-87-3
Molecular Formula:C₄₃H₇₆O₂Si₂
Molecular Weight:681.246
Hs Code.:

Synonyms:(7R,8S,10S)-10-Benzyloxy-7-(tert-butyldimethylsilyloxymethyl)-8-dimethyl(phenyl)silylhenicosane

Suppliers and Price of (7R,8S,10S)-10-Benzyloxy-7-(tert-butyldimethylsilyloxymethyl)-8-dimethyl(phenyl)silylhenicosane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (7R,8S,10S)-10-Benzyloxy-7-(tert-butyldimethylsilyloxymethyl)-8-dimethyl(phenyl)silylhenicosane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (7R,8S,10S)-10-Benzyloxy-7-(tert-butyldimethylsilyloxymethyl)-8-dimethyl(phenyl)silylhenicosane

There total 26 articles about (7R,8S,10S)-10-Benzyloxy-7-(tert-butyldimethylsilyloxymethyl)-8-dimethyl(phenyl)silylhenicosane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 130625-78-4
(7R,8S,10S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-8-(dimethyl-phenyl-silanyl)-henicosan-10-ol

: 130645-87-3
(7R,8S,10S)-10-Benzyloxy-7-(tert-butyldimethylsilyloxymethyl)-8-dimethyl(phenyl)silylhenicosane

Guidance literature:: trifluorormethanesulfonic acid; In dichloromethane; cyclohexane; for 3h; Ambient temperature;
DOI:10.1016/S0040-4039(00)94466-6

Reference yield:

: 26186-02-7
tridec-1-yne

: 130645-87-3
(7R,8S,10S)-10-Benzyloxy-7-(tert-butyldimethylsilyloxymethyl)-8-dimethyl(phenyl)silylhenicosane

Guidance literature:: Multi-step reaction with 11 steps

1: 86 percent / BuLi / tetrahydrofuran / 18 h / Heating

2: 1.) dicyclohexylborane, 2.) AcOH / 1.) THF, r.t., 2 h, 2.) THF, r.t., 1 h

3: Br₂ / CH₂Cl₂ / 0.17 h / -78 °C

4: NaOMe / methanol / 1.) 0 deg C, 1 h, 2.) r.t., 2 h

6: 43 percent / n-BuLi / tetrahydrofuran; hexane / 24 h / Ambient temperature

7: 51 percent / LDA / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) -78 deg C, 1 h

8: LiAlH₄ / diethyl ether / 3 h / 0 °C

9: imidazole / dimethylformamide / 1 h / Ambient temperature

10: 1.) 9-BBN, 2.) NaOH, H₂O₂ / 1.) reflux, 24 h

11: 91 percent / TfOH / cyclohexane; CH₂Cl₂ / 0.5 h / Ambient temperature

With 1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; trifluorormethanesulfonic acid; bis(cyclohexanyl)borane; dihydrogen peroxide; bromine; sodium methylate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1039/a804275f

Reference yield:

: 214683-72-4
(Z)-(2R,3S)-3-(Dimethyl-phenyl-silanyl)-2-hexyl-hexadec-4-en-1-ol

: 130645-87-3
(7R,8S,10S)-10-Benzyloxy-7-(tert-butyldimethylsilyloxymethyl)-8-dimethyl(phenyl)silylhenicosane

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 1 h / Ambient temperature

2: 1.) 9-BBN, 2.) NaOH, H₂O₂ / 1.) reflux, 24 h

3: 91 percent / TfOH / cyclohexane; CH₂Cl₂ / 0.5 h / Ambient temperature

With 1H-imidazole; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; trifluorormethanesulfonic acid; dihydrogen peroxide; In dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1039/a804275f