3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid hydrazide

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Chemical Name:3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid hydrazide
CAS No.:168464-71-9
Molecular Formula:C₁₈H₂₂N₆O₃
Molecular Weight:370.411
Hs Code.:

Synonyms:3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid hydrazide

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Chemical Property of 3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid hydrazide

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Technology Process of 3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid hydrazide

There total 8 articles about 3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 168465-03-0
3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid methyl ester

: 168464-71-9
3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid hydrazide

Guidance literature:: With hydrazine hydrate; In ethanol; for 16h; Heating;
DOI:10.1021/jm950812j

Reference yield:

: 54090-36-7
2-propoxybenzoyl chloride

: 168464-71-9
3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid hydrazide

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / a) RT, b) 45 deg C

2: aq. NaOH, 30percent H₂O₂ / 90 °C

3: 89 percent / AlCl₃ / CH₂Cl₂ / 48 h / Ambient temperature

4: Br₂, aq. NaOH / 2 h / Ambient temperature

5: conc. H₂SO₄ / 18 h / Heating

6: 84 percent / hydrazine hydrate / ethanol / 16 h / Heating

With pyridine; sodium hydroxide; aluminium trichloride; sulfuric acid; dihydrogen peroxide; bromine; hydrazine hydrate; In ethanol; dichloromethane;
DOI:10.1021/jm950812j

Reference yield:

: 102997-29-5
5-amino-4-cyano-3-methyl-1-ethyl-(1H)-pyrazole

: 168464-71-9
3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid hydrazide

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / a) RT, b) 45 deg C

2: aq. NaOH, 30percent H₂O₂ / 90 °C

3: 89 percent / AlCl₃ / CH₂Cl₂ / 48 h / Ambient temperature

4: Br₂, aq. NaOH / 2 h / Ambient temperature

5: conc. H₂SO₄ / 18 h / Heating

6: 84 percent / hydrazine hydrate / ethanol / 16 h / Heating

With pyridine; sodium hydroxide; aluminium trichloride; sulfuric acid; dihydrogen peroxide; bromine; hydrazine hydrate; In ethanol; dichloromethane;
DOI:10.1021/jm950812j