3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid methyl ester

Base Information

• Chemical Name: 3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid methyl ester
• CAS No.: 168465-03-0
• Molecular Formula: C₁₉H₂₂N₄O₄
• Molecular Weight: 370.408
• Mol file: 168465-03-0.mol

Synonyms:3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid methyl ester

Chemical Property of 3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid methyl ester

There total 7 articles about 3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-propoxybenzoyl chloride (54090-36-7) → 3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid methyl ester (168465-03-0)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / a) RT, b) 45 deg C

2: aq. NaOH, 30percent H₂O₂ / 90 °C

3: 89 percent / AlCl₃ / CH₂Cl₂ / 48 h / Ambient temperature

4: Br₂, aq. NaOH / 2 h / Ambient temperature

5: conc. H₂SO₄ / 18 h / Heating

With pyridine; sodium hydroxide; aluminium trichloride; sulfuric acid; dihydrogen peroxide; bromine; In dichloromethane;

DOI:10.1021/jm950812j

Reference yield:

5-amino-4-cyano-3-methyl-1-ethyl-(1H)-pyrazole (102997-29-5) → 3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid methyl ester (168465-03-0)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / a) RT, b) 45 deg C

2: aq. NaOH, 30percent H₂O₂ / 90 °C

3: 89 percent / AlCl₃ / CH₂Cl₂ / 48 h / Ambient temperature

4: Br₂, aq. NaOH / 2 h / Ambient temperature

5: conc. H₂SO₄ / 18 h / Heating

With pyridine; sodium hydroxide; aluminium trichloride; sulfuric acid; dihydrogen peroxide; bromine; In dichloromethane;

DOI:10.1021/jm950812j

Reference yield:

1-Ethyl-3-methyl-6-(2-propoxy-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (175406-88-9) → 3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid methyl ester (168465-03-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / AlCl₃ / CH₂Cl₂ / 48 h / Ambient temperature

2: Br₂, aq. NaOH / 2 h / Ambient temperature

3: conc. H₂SO₄ / 18 h / Heating

With sodium hydroxide; aluminium trichloride; sulfuric acid; bromine; In dichloromethane;

DOI:10.1021/jm950812j

upstream raw materials:

methanol

2-propoxybenzoyl chloride

5-amino-4-cyano-3-methyl-1-ethyl-(1H)-pyrazole

1-Ethyl-3-methyl-6-(2-propoxy-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Downstream raw materials:

3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid hydrazide