C₃₁H₃₉NO₅

Base Information

• Chemical Name: C₃₁H₃₉NO₅
• CAS No.: 1616556-70-7
• Molecular Formula: C₃₁H₃₉NO₅
• Molecular Weight: 505.654
• Mol file: 1616556-70-7.mol

Synonyms:C₃₁H₃₉NO₅

Chemical Property of C₃₁H₃₉NO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₃₉NO₅

There total 12 articles about C₃₁H₃₉NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C40H51NO5Si (1616556-69-4) + benzyl bromide (100-39-0) → C31H39NO5 (1616556-70-7)

Guidance literature:

C₄₀H₅₁NO₅Si; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

Naloxone methyl ether (131830-09-6,70866-64-7) → C31H39NO5 (1616556-70-7)

Guidance literature:

Multi-step reaction with 11 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-amino-2-propene; 1,3-dimethylbarbituric acid / dichloromethane / 2 h / 40 °C / Inert atmosphere

2.1: potassium carbonate / acetonitrile / 18 h / Reflux

3.1: zinc; ammonium chloride / acetone; water / 4.5 h / 60 °C

4.1: caesium carbonate / tetrahydrofuran / 70 °C

5.1: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylsilane / tetrahydrofuran / 20 °C

6.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 - -10 °C

6.2: -78 - 20 °C

7.1: boron tribromide / dichloromethane / 0.25 h / 0 °C

8.1: toluene-4-sulfonic acid / benzene / 1 h / Reflux; Dean-Stark

9.1: 1H-imidazole / N,N-dimethyl-formamide / 120 h / 20 °C

10.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -78 - -30 °C

11.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

11.2: 4 h / 20 °C

With 1H-imidazole; triethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; sodium hexamethyldisilazane; boron tribromide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; caesium carbonate; toluene-4-sulfonic acid; 1-amino-2-propene; zinc; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile; benzene;

Reference yield:

C24H31NO5 (1616556-64-9) → C31H39NO5 (1616556-70-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / benzene / 1 h / Reflux; Dean-Stark

2.1: 1H-imidazole / N,N-dimethyl-formamide / 120 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -78 - -30 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 4 h / 20 °C

With 1H-imidazole; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; In hexane; dichloromethane; N,N-dimethyl-formamide; benzene;

upstream raw materials:

C₄₀H₅₁NO₅Si

benzyl bromide

C₂₄H₃₁NO₅

C₂₆H₃₅NO₆

Downstream raw materials:

(4bR,7S,8aS,9R)-3-(benzyloxy)-11-(cyclopropylmethyl)-8a-hydroxy-7-(2-hydroxyethyl)-8,8a,9,10-tetrahydro-5H-9,4b-(epiminoethano)phenanthren-6(7H)-one