Cholan-24-oic acid,3-hydroxy-7-oxo-, phenylmethyl ester,(3α,5β)-

Base Information

Chemical Name:Cholan-24-oic acid,3-hydroxy-7-oxo-, phenylmethyl ester,(3α,5β)-
CAS No.:1352328-64-3
Molecular Formula:C₃₁H₄₄O₄
Molecular Weight:480.688
Hs Code.:
Mol file:1352328-64-3.mol

Synonyms:3α-hydroxy-7-keto-5β-24-cholanic acid benzyl ester

Suppliers and Price of Cholan-24-oic acid,3-hydroxy-7-oxo-, phenylmethyl ester,(3α,5β)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Phenylmethyl(3α,5β)-3-Hydroxy-7-oxo-cholan-24-oicAcidEster
100mg
$ 1715.00

TRC
Phenylmethyl(3α,5β)-3-Hydroxy-7-oxo-cholan-24-oicAcidEster
50mg
$ 980.00

Crysdot
(R)-Benzyl4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate 97%
100mg
$ 396.00

Total 1 raw suppliers

Chemical Property of Cholan-24-oic acid,3-hydroxy-7-oxo-, phenylmethyl ester,(3α,5β)-

Chemical Property:

Boiling Point:588.4±30.0 °C(Predicted)
PKA:15.02±0.70(Predicted)
Density:1.109±0.06 g/cm3(Predicted)
Solubility.:Dichloromethane; Ethyl Acetate; Methanol;

Purity/Quality:: Phenylmethyl(3α,5β)-3-Hydroxy-7-oxo-cholan-24-oicAcidEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Phenylmethyl (3α,5β)-3-Hydroxy-7-oxo-cholan-24-oic Acid Ester is an intermediate used in the synthesis of 6-Ethylchenodeoxycholic-d5 Acid (E899812), which is an isotope labelled compound of 6-Ethylchenodeoxycholic Acid (E899810), which is used in the investigative treatment of primary biliary cholangitis. Primary biliary cholangitis is an autoimmune disease of the liver that slowly progresses to cirrhosis.

Technology Process of Cholan-24-oic acid,3-hydroxy-7-oxo-, phenylmethyl ester,(3α,5β)-

There total 3 articles about Cholan-24-oic acid,3-hydroxy-7-oxo-, phenylmethyl ester,(3α,5β)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.1%

: 4651-67-6
7-Ketolithocholic acid

: 100-39-0
benzyl bromide

: 1352328-64-3
3α-hydroxy-7-keto-5β-24-cholanic acid benzyl ester

Guidance literature:: 7-Ketolithocholic acid; With potassium carbonate; In tetrahydrofuran; for 1h; Reflux;

benzyl bromide; In tetrahydrofuran; for 12h;

Reference yield: 95.0%

: 4651-67-6
7-Ketolithocholic acid

: 100-44-7
benzyl chloride

: 1352328-64-3
3α-hydroxy-7-keto-5β-24-cholanic acid benzyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 - 60 ℃;

Reference yield:

: 474-25-9
chenodeoxycholic acid

: 1352328-64-3
3α-hydroxy-7-keto-5β-24-cholanic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium bromide; acetic acid; sodium hypochlorite; sodium hydrogen sulfate / methanol / 0.5 h / -10 - 20 °C

2: potassium carbonate / tetrahydrofuran / 12 h / Reflux

With sodium hypochlorite; sodium hydrogen sulfate; potassium carbonate; acetic acid; sodium bromide; In tetrahydrofuran; methanol;