2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carboxime

Base Information

Chemical Name:2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carboxime
CAS No.:1442652-37-0
Molecular Formula:C₁₉H₁₆F₂N₂O₃S
Molecular Weight:390.41
Hs Code.:

Synonyms:2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carboxime

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Chemical Property of 2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carboxime

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Technology Process of 2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carboxime

There total 4 articles about 2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carboxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1442652-33-6
2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carboxaldehyde

: 1442652-37-0
2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carboxime

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; In ethanol; water; for 1.5h; Reflux;
DOI:10.1016/j.bmc.2013.04.031

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1442652-37-0
2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carboxime

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / 0.25 h / 70 °C / 7757.43 Torr / Microwave irradiation

2: oxone / methanol; water / 2.08 h / 25 °C

3: toluene-4-sulfonic acid / ethanol / 0.75 h / 160 °C / 7757.43 Torr / Microwave irradiation

4: trichlorophosphate / dichloromethane / 1.05 h / 0 °C / Reflux

5: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 1.5 h / Reflux

With oxone; hydroxylamine hydrochloride; sodium acetate; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; toluene-4-sulfonic acid; triethylamine; trichlorophosphate; In methanol; ethanol; dichloromethane; water; 1: |Stetter 1,4-Dicarbonyl Synthesis / 3: |Paal-Knorr Pyrrole Synthesis;
DOI:10.1016/j.bmc.2013.04.031

Reference yield:

: 189501-33-5
1-[4-(methylthio)phenyl]pentane-1,4-dione

: 1442652-37-0
2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carboxime

Guidance literature:: Multi-step reaction with 4 steps

1: oxone / methanol; water / 2.08 h / 25 °C

2: toluene-4-sulfonic acid / ethanol / 0.75 h / 160 °C / 7757.43 Torr / Microwave irradiation

3: trichlorophosphate / dichloromethane / 1.05 h / 0 °C / Reflux

4: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 1.5 h / Reflux

With oxone; hydroxylamine hydrochloride; sodium acetate; toluene-4-sulfonic acid; trichlorophosphate; In methanol; ethanol; dichloromethane; water; 2: |Paal-Knorr Pyrrole Synthesis;
DOI:10.1016/j.bmc.2013.04.031