2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carbonitrile

Base Information

Chemical Name:2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carbonitrile
CAS No.:1442652-40-5
Molecular Formula:C₁₉H₁₄F₂N₂O₂S
Molecular Weight:372.395
Hs Code.:

Synonyms:2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carbonitrile

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Chemical Property of 2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carbonitrile

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Technology Process of 2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carbonitrile

There total 6 articles about 2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1442652-37-0
2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carboxime

: 1442652-40-5
2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carbonitrile

Guidance literature:: With 1,3,5-trichloro-2,4,6-triazine; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1016/j.bmc.2013.04.031

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1442652-40-5
2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / 0.25 h / 70 °C / 7757.43 Torr / Microwave irradiation

2: oxone / methanol; water / 2.08 h / 25 °C

3: toluene-4-sulfonic acid / ethanol / 0.75 h / 160 °C / 7757.43 Torr / Microwave irradiation

4: trichlorophosphate / dichloromethane / 1.05 h / 0 °C / Reflux

5: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 1.5 h / Reflux

6: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 8 h / 20 °C

With 1,3,5-trichloro-2,4,6-triazine; oxone; hydroxylamine hydrochloride; sodium acetate; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; toluene-4-sulfonic acid; triethylamine; trichlorophosphate; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: |Stetter 1,4-Dicarbonyl Synthesis / 3: |Paal-Knorr Pyrrole Synthesis;
DOI:10.1016/j.bmc.2013.04.031

Reference yield:

: 189501-34-6
1-[4-(methylsulfonyl)phenyl]pentane-1,4-dione

: 1442652-40-5
2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3,4-difluorophenyl]-1H-pyrrole-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / ethanol / 0.75 h / 160 °C / 7757.43 Torr / Microwave irradiation

2: trichlorophosphate / dichloromethane / 1.05 h / 0 °C / Reflux

3: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 1.5 h / Reflux

4: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 8 h / 20 °C

With 1,3,5-trichloro-2,4,6-triazine; hydroxylamine hydrochloride; sodium acetate; toluene-4-sulfonic acid; trichlorophosphate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: |Paal-Knorr Pyrrole Synthesis;
DOI:10.1016/j.bmc.2013.04.031