Methyl 1-[4-(1-pyrrolidinyl)phenyl]cyclopentanecarboxylate

Base Information

Chemical Name:Methyl 1-[4-(1-pyrrolidinyl)phenyl]cyclopentanecarboxylate
CAS No.:135569-21-0
Molecular Formula:C₁₇H₂₃NO₂
Molecular Weight:273.375
Hs Code.:
DSSTox Substance ID:DTXSID901194592

Synonyms:Methyl 1-[4-(1-pyrrolidinyl)phenyl]cyclopentanecarboxylate;DTXSID901194592;135569-21-0

Suppliers and Price of Methyl 1-[4-(1-pyrrolidinyl)phenyl]cyclopentanecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 1-[4-(1-pyrrolidinyl)phenyl]cyclopentanecarboxylate

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:273.172878976
Heavy Atom Count:20
Complexity:335

Purity/Quality:

Safty Information:

Pictogram(s):
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MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1(CCCC1)C2=CC=C(C=C2)N3CCCC3

Technology Process of Methyl 1-[4-(1-pyrrolidinyl)phenyl]cyclopentanecarboxylate

There total 4 articles about Methyl 1-[4-(1-pyrrolidinyl)phenyl]cyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 110-52-1
1,4-dibromo-butane

: 135569-20-9
methyl 1-(p-aminophenyl)cyclopentanecarboxylate

: 135569-21-0
methyl 1-(p-1-pyrrolidinylphenyl)cyclopentanecarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 75 - 80 ℃; for 12h;
DOI:10.1021/jm00114a005

Reference yield:

: 52648-77-8
1-(4-nitro-phenyl)-cyclopentanecarboxylic acid

: 135569-21-0
methyl 1-(p-1-pyrrolidinylphenyl)cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / benzene / 4 h / Heating

2: 78 percent / benzene / 4 h / Heating

3: 77 percent / H₂ / 10percent Pt/C / methanol

4: 63 percent / K₂CO₃ / dimethylformamide / 12 h / 75 - 80 °C

With thionyl chloride; hydrogen; potassium carbonate; platinum on activated charcoal; In methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00114a005

Reference yield:

: 422280-34-0
1-(4-nitro-phenyl)-cyclopentanecarbonyl chloride

: 135569-21-0
methyl 1-(p-1-pyrrolidinylphenyl)cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / benzene / 4 h / Heating

2: 77 percent / H₂ / 10percent Pt/C / methanol

3: 63 percent / K₂CO₃ / dimethylformamide / 12 h / 75 - 80 °C

With hydrogen; potassium carbonate; platinum on activated charcoal; In methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00114a005