(6-{5-[tert-butoxycarbonyl-(3-pyridin-4-yl-propyl)-amino]-pyridin-3-yl}-pyrazin-2-yl)-(4-chloro-phenyl)-carbamic acid tert-butyl ester

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Chemical Name:(6-{5-[tert-butoxycarbonyl-(3-pyridin-4-yl-propyl)-amino]-pyridin-3-yl}-pyrazin-2-yl)-(4-chloro-phenyl)-carbamic acid tert-butyl ester
CAS No.:405939-75-5
Molecular Formula:C₃₃H₃₇ClN₆O₄
Molecular Weight:617.148
Hs Code.:

(6-{5-[<i>tert</i>-butoxycarbonyl-(3-pyridin-4-yl-propyl)-amino]-pyridin-3-yl}-pyrazin-2-yl)-(4-chloro-phenyl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(6-{5-[tert-butoxycarbonyl-(3-pyridin-4-yl-propyl)-amino]-pyridin-3-yl}-pyrazin-2-yl)-(4-chloro-phenyl)-carbamic acid tert-butyl ester

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Chemical Property of (6-{5-[tert-butoxycarbonyl-(3-pyridin-4-yl-propyl)-amino]-pyridin-3-yl}-pyrazin-2-yl)-(4-chloro-phenyl)-carbamic acid tert-butyl ester

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Technology Process of (6-{5-[tert-butoxycarbonyl-(3-pyridin-4-yl-propyl)-amino]-pyridin-3-yl}-pyrazin-2-yl)-(4-chloro-phenyl)-carbamic acid tert-butyl ester

There total 4 articles about (6-{5-[tert-butoxycarbonyl-(3-pyridin-4-yl-propyl)-amino]-pyridin-3-yl}-pyrazin-2-yl)-(4-chloro-phenyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 405939-08-4
[6-(5-tert-butoxycarbonylaminopyridin-3-yl)pyrazin-2-yl]-(4-chlorophenyl)carbamic acid tert-butyl ester

: 5264-02-8
3-(4-pyridyl)-1-chloropropane

: 405939-75-5
(6-{5-[tert-butoxycarbonyl-(3-pyridin-4-yl-propyl)-amino]-pyridin-3-yl}-pyrazin-2-yl)-(4-chloro-phenyl)-carbamic acid tert-butyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 20h;
DOI:10.1021/jm058205b

Reference yield:

: 862536-35-4
5-{6-[tert-butoxycarbonyl-(4-chlorophenyl)amino]pyrazin-2-yl}nicotinic acid

: 405939-75-5
(6-{5-[tert-butoxycarbonyl-(3-pyridin-4-yl-propyl)-amino]-pyridin-3-yl}-pyrazin-2-yl)-(4-chloro-phenyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / diphenylphosphoryl azide; triethylamine / toluene / 4.5 h / 70 - 100 °C

2: Cs₂CO₃ / dimethylformamide / 20 h / 70 °C

With diphenylphosphoranyl azide; caesium carbonate; triethylamine; In N,N-dimethyl-formamide; toluene; 1: Curtius rearrangement;
DOI:10.1021/jm058205b

Reference yield:

: 405939-07-3
5-{6-[tert-butoxycarbonyl-(4-chloro-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester

: 405939-75-5
(6-{5-[tert-butoxycarbonyl-(3-pyridin-4-yl-propyl)-amino]-pyridin-3-yl}-pyrazin-2-yl)-(4-chloro-phenyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH / methanol / 18.3 h / 0 - 20 °C

2: 55 percent / diphenylphosphoryl azide; triethylamine / toluene / 4.5 h / 70 - 100 °C

3: Cs₂CO₃ / dimethylformamide / 20 h / 70 °C

With sodium hydroxide; diphenylphosphoranyl azide; caesium carbonate; triethylamine; In methanol; N,N-dimethyl-formamide; toluene; 2: Curtius rearrangement;
DOI:10.1021/jm058205b