5264-02-8

Basic information

• Product Name: Pyridine, 4-(3-chloropropyl)-
• Synonyms: 4-(3-CHLORO-PROPYL)-PYRIDINE;Pyridine,4-(3-chloropropyl)
• CAS NO: 5264-02-8
• Molecular Formula: C8H10ClN
• Molecular Weight: 155.627
• Mol File: 5264-02-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Pyridine, 4-(3-chloropropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-(3-chloropropyl)-(5264-02-8)
• EPA Substance Registry System: Pyridine, 4-(3-chloropropyl)-(5264-02-8)

Safety Data

• Hazardous Substances Data: 5264-02-8(Hazardous Substances Data)

Upstream product

• 2629-72-3 4-(3-Hydroxypropyl)pyridine 
• 110-86-1 pyridine 
• 59137-44-9 3-carboxy-2-(pyridin-1-ium-1-yl)propanoate 
• 108-89-4 picoline 
• 107-04-0 1-Bromo-2-chloroethane 

Downstream Products

• 84200-09-9 4-(3-cyanopropyl)pyridine 
• 5264-15-3 4-(4-pyridinyl)butan-1-ol 
• 118892-71-0 cis-4-(3-phosphonoprop-1-yl)piperidine-2-carboxylic acid 
• 189938-86-1 N-(4-Pyridin-4-yl-butyl)-acetamide 
• 145301-48-0 BIBN 99 
• 102878-73-9 γ-(pyridin-4-yl)butyric acid 
• 405939-17-5 (6-{5-[tert-butoxycarbonyl-(3-pyridin-4-yl-propyl)-amino]-pyridin-3-yl}-pyrazin-2-yl)-(3,4-dichloro-phenyl)-carbamic acid tert-butyl ester 
• 405939-75-5 (6-{5-[tert-butoxycarbonyl-(3-pyridin-4-yl-propyl)-amino]-pyridin-3-yl}-pyrazin-2-yl)-(4-chloro-phenyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Practical and Regioselective Synthesis of C-4-Alkylated Pyridines

The direct position-selective C-4 alkylation of pyridines has been a long-standing challenge in heterocyclic chemistry, particularly from pyridine itself. Historically this has been addressed using prefunctionalized materials to avoid overalkylation and mixtures of regioisomers. This study reports the invention of a simple maleate-derived blocking group for pyridines that enables exquisite control for Minisci-type decarboxylative alkylation at C-4 that allows for inexpensive access to these valuable building blocks. The method is employed on a variety of different pyridines and carboxylic acid alkyl donors, is operationally simple and scalable, and is applied to access known structures in a rapid and inexpensive fashion. Finally, this work points to an interesting strategic departure for the use of Minisci chemistry at the earliest possible stage (native pyridine) rather than current dogma that almost exclusively employs Minisci chemistry as a late-stage functionalization technique.

AZETIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Compounds of formula [I]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salts or solvates thereof.

Fibrinogen receptor antagonists

Fibrinogen receptor antagonists having the structure, for example, of STR1 for example STR2