Technology Process of [(4S,5R)-1,4,5-trimethyl-4-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]carbamic acid tert-butyl ester
There total 6 articles about [(4S,5R)-1,4,5-trimethyl-4-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]carbamic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
[(S)-1,4-dimethyl-4-(3-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
methyl iodide;
In
tetrahydrofuran;
at -78 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 22 °C
1.2: 0.25 h / 22 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 22 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
3.2: 1.5 h / -78 °C
With
sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 0.5 h / -78 °C
1.3: 3 h / -78 °C
2.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 22 °C
2.2: pH ~ 10
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 22 °C
4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
4.2: 1.5 h / -78 °C
With
hydrogenchloride; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; methanol; hexane; N,N-dimethyl-formamide;
![[(S)-1,4-dimethyl-4-(3-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester](/Databaselist/images/loading.webp)
