ethyl 7-(2,3-bis(3-fluoro-4-methylphenyl)-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

Base Information

Chemical Name:ethyl 7-(2,3-bis(3-fluoro-4-methylphenyl)-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate
CAS No.:1356332-92-7
Molecular Formula:C₃₀H₃₅F₂N₃O₂
Molecular Weight:507.624
Hs Code.:

Synonyms:ethyl 7-(2,3-bis(3-fluoro-4-methylphenyl)-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

Suppliers and Price of ethyl 7-(2,3-bis(3-fluoro-4-methylphenyl)-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 7-(2,3-bis(3-fluoro-4-methylphenyl)-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 7-(2,3-bis(3-fluoro-4-methylphenyl)-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

There total 6 articles about ethyl 7-(2,3-bis(3-fluoro-4-methylphenyl)-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3990-05-4
ethyl 6-formylhexanoate

: 1356332-46-1
2,3-bis(3-fluoro-4-methylphenyl)-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine

: 1356332-92-7
ethyl 7-(2,3-bis(3-fluoro-4-methylphenyl)-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

Guidance literature:: ethyl 6-formylhexanoate; 2,3-bis(3-fluoro-4-methylphenyl)-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine; With triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 0.25h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 60 ℃; for 18h;

Reference yield:

: 91243-58-2
7-ethyloxyheptanoic acid ethyl ester

: 1356332-46-1
2,3-bis(3-fluoro-4-methylphenyl)-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine

: 1356332-92-7
ethyl 7-(2,3-bis(3-fluoro-4-methylphenyl)-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

Guidance literature:: 7-ethyloxyheptanoic acid ethyl ester; 2,3-bis(3-fluoro-4-methylphenyl)-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine; With triethylamine; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; at 60 ℃; for 18h;

Reference yield:

: 452-58-4
2,3-Diaminopyridine

: 1356332-92-7
ethyl 7-(2,3-bis(3-fluoro-4-methylphenyl)-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1 h / 120 °C / Inert atmosphere

2.1: trichlorophosphate / 8 h / 110 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 4 h / 150 °C / Inert atmosphere; microwave irradiation

4.1: ammonium formate / 20% palladium hydroxide-activated charcoal / water; methanol / 11 h / Reflux

5.1: triethylamine / 1,2-dichloro-ethane / 0.25 h / 20 °C

5.2: 18 h / 60 °C

With ammonium formate; potassium carbonate; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; In 1,4-dioxane; methanol; water; 1,2-dichloro-ethane;