2,3-Dichloropyrido[2,3-b]pyrazine

Base Information

• Chemical Name: 2,3-Dichloropyrido[2,3-b]pyrazine
• CAS No.: 25710-18-3
• Molecular Formula: C7H3 Cl2 N3
• Molecular Weight: 200.027
• Hs Code.: 2933990090
• European Community (EC) Number: 818-278-4
• DSSTox Substance ID: DTXSID70472674
• Nikkaji Number: J2.166.168F
• Wikidata: Q82301719
• Mol file: 25710-18-3.mol

Synonyms:2,3-dichloropyrido[2,3-b]pyrazine;25710-18-3;2,3-Dichloro-pyrido[2,3-b]pyrazine;2,3-dichloro-pyrido(2,3-b)pyrazine;4,4-Dimethoxydiphenylsulfide;SCHEMBL362277;DTXSID70472674;HWJDFFLZOOKZNL-UHFFFAOYSA-N;AMY11906;2,3-Dichloropyrido[3,2-b]pyrazine;MFCD09031107;AKOS015917827;AC-28844;DS-17180;CS-0076788;FT-0686793;EN300-106294;F30139;A911352;J-506939;F6170-0031;Z1269208204

Chemical Property of 2,3-Dichloropyrido[2,3-b]pyrazine

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Melting Point: 144-146 °C
• Refractive Index: 1.682
• Boiling Point: 282.342°C at 760 mmHg
• PKA: -1.19±0.30(Predicted)
• Flash Point: 151.584°C
• PSA: 38.67000
• Density: 1.573g/cm³
• LogP: 2.33160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 198.9704025
• Heavy Atom Count: 12
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

2,3-dichloropyrido[2,3-b]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC2=C(N=C1)N=C(C(=N2)Cl)Cl

Technology Process of 2,3-Dichloropyrido[2,3-b]pyrazine

There total 5 articles about 2,3-Dichloropyrido[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

NSC 91561 (2067-84-7) → 2,3-Dichloro-pyrido[2,3-b]pyrazine (25710-18-3)

Guidance literature:

With trichlorophosphate; for 24h; Reflux;

DOI:10.1002/bkcs.10335

Reference yield: 78.0%

pyrido[3,2-b]pyrazine-2,3-diol (2067-84-7) → 2,3-Dichloro-pyrido[2,3-b]pyrazine (25710-18-3)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In chloroform; for 24h; Reflux;

DOI:10.1016/j.bmc.2011.07.028

Reference yield:

2,3-Diaminopyridine (452-58-4) → 2,3-Dichloro-pyrido[2,3-b]pyrazine (25710-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / aq. HCl / 6 h / Heating

2: 80 percent / SOCl₂; DMF / 10 h / Heating

With hydrogenchloride; thionyl chloride; N,N-dimethyl-formamide;

DOI:10.1021/jo0478398

upstream raw materials:

NSC 91561

2,3-Diaminopyridine

oxalic acid

pyrido[3,2-b]pyrazine-2,3-diol

Downstream raw materials:

2-chloro-3-(phenylethynyl)pyrido[3,2-b]pyrazine

2,3-bis(p-tolylethynyl)pyrido[2,3-b]pyrazine