[2-benzyloxy-6-(tert-butyldimethylsilyloxymethyl)-3,6-dihydro-2H-pyran-3-yl]acetaldehyde

Base Information

Chemical Name:[2-benzyloxy-6-(tert-butyldimethylsilyloxymethyl)-3,6-dihydro-2H-pyran-3-yl]acetaldehyde
CAS No.:500222-34-4
Molecular Formula:C₂₁H₃₂O₄Si
Molecular Weight:376.568
Hs Code.:

Synonyms:[2-benzyloxy-6-(tert-butyldimethylsilyloxymethyl)-3,6-dihydro-2H-pyran-3-yl]acetaldehyde

Suppliers and Price of [2-benzyloxy-6-(tert-butyldimethylsilyloxymethyl)-3,6-dihydro-2H-pyran-3-yl]acetaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-benzyloxy-6-(tert-butyldimethylsilyloxymethyl)-3,6-dihydro-2H-pyran-3-yl]acetaldehyde

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [2-benzyloxy-6-(tert-butyldimethylsilyloxymethyl)-3,6-dihydro-2H-pyran-3-yl]acetaldehyde

There total 7 articles about [2-benzyloxy-6-(tert-butyldimethylsilyloxymethyl)-3,6-dihydro-2H-pyran-3-yl]acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 500222-33-3
2-[(2S,3R,6S)-2-benzyloxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-3,6-dihydro-2H-pyran-3-yl]ethanol

: 500222-34-4
[2-benzyloxy-6-(tert-butyldimethylsilyloxymethyl)-3,6-dihydro-2H-pyran-3-yl]acetaldehyde

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; for 2h;
DOI:10.1081/CAR-120014904

Reference yield:

: 81389-87-9
(2R,3S,6S)-6-(benzyloxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-3,6-dihydro-2H-pyran-3-ol

: 500222-34-4
[2-benzyloxy-6-(tert-butyldimethylsilyloxymethyl)-3,6-dihydro-2H-pyran-3-yl]acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / propionic acid / xylene / 48 h / Heating

2: 93 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 - 20 °C

3: 92 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

With lithium aluminium tetrahydride; propionic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; xylene;
DOI:10.1081/CAR-120014904

Reference yield:

: 81389-86-8
(2R,3S,6S)-6-(benzyloxy)-2-(hydroxymethyl)-3,6-dihydro-2H-pyran-3-ol

: 500222-34-4
[2-benzyloxy-6-(tert-butyldimethylsilyloxymethyl)-3,6-dihydro-2H-pyran-3-yl]acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / imidazole / CH₂Cl₂ / 3 h / 0 °C

2: 86 percent / propionic acid / xylene / 48 h / Heating

3: 93 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 - 20 °C

4: 92 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

With 1H-imidazole; lithium aluminium tetrahydride; propionic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; xylene;
DOI:10.1081/CAR-120014904