(S)-4-methyl-N-((methyldiphenylsilyl)(phenyl)methyl)benzenesulfonamide

Base Information

Chemical Name:(S)-4-methyl-N-((methyldiphenylsilyl)(phenyl)methyl)benzenesulfonamide
CAS No.:1586870-05-4
Molecular Formula:C₂₇H₂₇NO₂SSi
Molecular Weight:457.668
Hs Code.:

Synonyms:(S)-4-methyl-N-((methyldiphenylsilyl)(phenyl)methyl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-methyl-N-((methyldiphenylsilyl)(phenyl)methyl)benzenesulfonamide

Chemical Property:

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Technology Process of (S)-4-methyl-N-((methyldiphenylsilyl)(phenyl)methyl)benzenesulfonamide

There total 7 articles about (S)-4-methyl-N-((methyldiphenylsilyl)(phenyl)methyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: (E)-4-methyl-N-((methyldiphenylsilyl)(phenyl)methylene)benzenesulfonamide

: 1586870-05-4
(S)-4-methyl-N-((methyldiphenylsilyl)(phenyl)methyl)benzenesulfonamide

Guidance literature:: With (R,R)-(?)-2,3-bis(t-butylmethylphosphino)quinoxaline; palladium(II) trifluoroacetate; hydrogen; In 2,2,2-trifluoroethanol; acetone; at 20 ℃; for 10h; under 30402 Torr; enantioselective reaction; Schlenk technique; Autoclave;
DOI:10.1021/acs.orglett.8b04073

Reference yield:

: 18666-54-1
(methyldiphenylsilyl)(phenyl)methanone

: 70-55-3
toluene-4-sulfonamide

: 1586870-05-4
(S)-4-methyl-N-((methyldiphenylsilyl)(phenyl)methyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: titanium tetrachloride; triethylamine / dichloromethane / Inert atmosphere

2: palladium(II) trifluoroacetate; (R,R)-(?)-2,3-bis(t-butylmethylphosphino)quinoxaline; hydrogen / acetone; 2,2,2-trifluoroethanol / 10 h / 20 °C / 30402 Torr / Schlenk technique; Autoclave

With (R,R)-(?)-2,3-bis(t-butylmethylphosphino)quinoxaline; palladium(II) trifluoroacetate; hydrogen; titanium tetrachloride; triethylamine; In dichloromethane; 2,2,2-trifluoroethanol; acetone;
DOI:10.1021/acs.orglett.8b04073

Reference yield:

: 1586869-93-3
N-((methyldiphenylsilyl)(phenyl)methylene)-p-toluenesulfonamide

: 1586870-05-4
(S)-4-methyl-N-((methyldiphenylsilyl)(phenyl)methyl)benzenesulfonamide

: N-((methyldiphenylsilyl)(phenyl)methyl)-p-toluenesulfonamide

Guidance literature:: With n-butyllithium; (S)-2,2-dimethyl-N-(2-(4-methylpiperazin-1-yl)-1-phenylethyl)propan-1-amine; In tetrahydrofuran; hexane; at -80 - 0 ℃; for 0.5h; Overall yield = 53 %; Overall yield = 39 mg; enantioselective reaction;
DOI:10.1021/jo500441a