2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-thiophen-2-ylacetamide

Base Information

Chemical Name:2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-thiophen-2-ylacetamide
CAS No.:1569319-94-3
Molecular Formula:C₁₇H₁₃ClFN₃OS
Molecular Weight:361.827
Hs Code.:

Synonyms:2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-thiophen-2-ylacetamide

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Chemical Property of 2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-thiophen-2-ylacetamide

Chemical Property:

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Technology Process of 2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-thiophen-2-ylacetamide

There total 4 articles about 2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-thiophen-2-ylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(5-bromopyridin-3-ylamino)-2-thiophen-2-ylacetamide

: 352535-83-2
5-chloro-2-fluorophenylboronic acid

: 1569319-94-3
2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-thiophen-2-ylacetamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 10h; Inert atmosphere;

Reference yield:

: (5-bromopyridin-3-ylamino)thiophen-2-ylacetonitrile

: 1569319-94-3
2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-thiophen-2-ylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 0.5 h / 40 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 10 h / 80 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water;

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 1569319-94-3
2-[5-(5-chloro-2-fluorophenyl)pyridin-3-ylamino]-2-thiophen-2-ylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1,2-dimethoxyethane / 20 °C / Reflux

2: hydrogenchloride / water / 0.5 h / 40 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 10 h / 80 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water;