ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-cyclopropylaminoacrylate

Base Information

Chemical Name:ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-cyclopropylaminoacrylate
CAS No.:117528-63-9
Molecular Formula:C₁₆H₁₃Cl₂FN₂O₃
Molecular Weight:371.195
Hs Code.:

Synonyms:ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-cyclopropylaminoacrylate

Suppliers and Price of ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-cyclopropylaminoacrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
(Z)-Ethyl 3-(cyclopropylamino)-2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)acrylate 95%
5g
$ 7586.00

Total 1 raw suppliers

Chemical Property of ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-cyclopropylaminoacrylate

Chemical Property:

Melting Point:65-67 °C
Boiling Point:542.3±50.0 °C(Predicted)
Density:1.44±0.1 g/cm3(Predicted)

Purity/Quality:

95%-98% ^*data from raw suppliers

(Z)-Ethyl 3-(cyclopropylamino)-2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)acrylate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-cyclopropylaminoacrylate

There total 5 articles about ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-cyclopropylaminoacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159908-25-4
C₁₅H₁₃Cl₂FN₂O₃

: 765-30-0
Cyclopropylamine

: 117528-63-9
ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-cyclopropylaminoacrylate

Guidance literature:: In diethyl ether; ethanol; at 20 ℃; for 1.5h;
DOI:10.1016/j.tetlet.2009.03.051

Reference yield:

: 117528-58-2
2,4-dichloro-3-cyano-5-fluorobenzoic acid

: 117528-63-9
ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-cyclopropylaminoacrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride; triethylamine / dichloromethane / 35 - 40 °C

1.2: 12 h / -5 - 20 °C

2.1: acetic acid / 12 h / 10 - 20 °C

With thionyl chloride; acetic acid; triethylamine; In dichloromethane;

Reference yield:

: 924-99-2,1117-37-9,114894-59-6
ethyl 3-(dimethylamino)acrylate

: 117528-63-9
ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-cyclopropylaminoacrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride; triethylamine / dichloromethane / 35 - 40 °C

1.2: 12 h / -5 - 20 °C

2.1: acetic acid / 12 h / 10 - 20 °C

With thionyl chloride; acetic acid; triethylamine; In dichloromethane;