Technology Process of 1-(4-methylbenzyl)-1H-pyrazolo[4,3-c]isoquinoline
There total 3 articles about 1-(4-methylbenzyl)-1H-pyrazolo[4,3-c]isoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 5h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/jo4025418
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate; copper(l) iodide; Trimethylacetic acid; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 120 °C / Schlenk technique; Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / Inert atmosphere; Schlenk technique
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; potassium carbonate; Trimethylacetic acid;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo4025418
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 90 °C / Inert atmosphere; Schlenk technique
2: potassium carbonate; copper(l) iodide; Trimethylacetic acid; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 120 °C / Schlenk technique; Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / Inert atmosphere; Schlenk technique
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; potassium carbonate; Trimethylacetic acid;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo4025418
