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Usage

Uses

Used in Pharmaceutical Synthesis:
1-(4-METHYL-BENZYL)-4-NITRO-1H-PYRAZOLE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 1-(4-METHYL-BENZYL)-4-NITRO-1H-PYRAZOLE is utilized as an intermediate for the production of pesticides and other agrochemicals, contributing to the development of more effective and environmentally friendly products.
Used in Dye and Pigment Manufacturing:
1-(4-METHYL-BENZYL)-4-NITRO-1H-PYRAZOLE is also used as an intermediate in the manufacturing of dyes and pigments, where its chemical properties enable the creation of a wide range of colors and shades for various applications.
Used in Medicine and Biotechnology Research:
Due to its demonstrated biological activity, 1-(4-METHYL-BENZYL)-4-NITRO-1H-PYRAZOLE is being studied for potential applications in medicine and biotechnology. Its unique properties may lead to the development of new therapeutic approaches and technologies in these fields.

Upstream product

• 2075-46-9 4-nitro-1H-pyrazole 
• 106-42-3 para-xylene 
• 104-81-4 4-Methylbenzyl bromide 

Downstream Products

• 1584233-80-6 1-(4-methylbenzyl)-4-nitro-3,5-bis(3-nitrophenyl)-1H-pyrazole 
• 1584233-87-3 1-(4-methylbenzyl)-7,8-dimethoxy-1H-pyrazolo[4,3-c]isoquinoline 
• 1584233-88-4 1-(4-methylbenzyl)-1H-pyrazolo[4,3-c]isoquinoline 
• 1584233-65-7 1-(4-methylbenzyl)-4-nitro-5-(3-nitrophenyl)-1H-pyrazole 
• 1584233-71-5 3-{1-[(4-methylphenyl)methyl]-4-nitro-1H-pyrazol-5-yl}pyridine 
• 1584233-70-4 5-(1-(4-methylbenzyl)-4-nitro-1H-pyrazol-5-yl)pyrimidine 
• 1584233-76-0 2-(1-(4-methylbenzyl)-4-nitro-1H-pyrazol-5-yl)-4,5-dimethoxybenzaldehyde 
• 1584233-75-9 2-(1-(4-methylbenzyl)-4-nitro-1H-pyrazol-5-yl)benzaldehyde 

Relevant academic research and scientific papers

Regioselective and guided C-H activation of 4-nitropyrazoles

A divergent and regioselective approach to 5-aryl-4-nitro-1H-pyrazoles was developed by guided transition-metal-catalyzed arylation of 4-nitro-1H- pyrazoles. This method provides a convenient tool for the functionalization of the pharmacologically relevan

Reactions of some arenes and pyrazoles in MeCN under conditions of undivided-cell electrolysis

As exemplified for the first time by pyrazole and its 4-nitro and 3,5-dimcthyl derivatives, N-arylation of pyrazoles can be performed under conditions of undivided-cell amperostatic electrolysis (Pt electrodes, McCN) of systems containing the pyrazolate anion and (or) pyrazole, arene (benzene, 1,4-dimethoxybenzene, or xylene), and a supporting electrolyte. In the case of electrolysis involving 1,4-dimethoxybenzene as arene, N-arylation followed simultaneously three routes to form an ortho-substitution product (1,4-dimethoxy-2-(pyrazol-1-yl)benzene), an ipso-substitution product (4-methoxy-1-(pyrazol-1-yl)benzene), and an ipso-bisaddition product (1,4-dimethoxy-1,4-di(pyrazol-1-yl)cyclohexa-2,5-diene) in a total current yield of up to 50%. The acid-base properties of the pyrazolcs under study affect the ratio of the N-arylation products and govern the required composition of the starting reaction mixture. In the case of a stronger base, such as 3,5-dimethylpyrazole, N-arylation with 1,4-dimethoxybenzene occurred even in the pyrazole-arene-tetraalkylammonium perchlorate system, whereas N-arylation of 4-nitropyrazole (a weaker base) proceeded only in the presence of the pyrazolate anion or another base, viz., sym-collidine. Oxidation of arene to the radical cation is the key anodic reaction. Not only the pyrazolate anion, but also highly basic pyrazole or a solvate complex of weakly basic pyrazole with collidine can serve as a nucleophilic partner in subsequent transformations of these radical cations.