5-(2-carboxy-trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde

Base Information

• Chemical Name: 5-(2-carboxy-trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde
• CAS No.: 144735-64-8
• Molecular Formula: C₂₀H₁₆O₇
• Molecular Weight: 368.343

Synonyms:5-(2-carboxy-trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde

Chemical Property of 5-(2-carboxy-trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-carboxy-trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde

There total 7 articles about 5-(2-carboxy-trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-(2-(methoxycarbonyl)-trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde (144735-63-7) → 5-(2-carboxy-trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde (144735-64-8)

Guidance literature:

With sodium hydroxide; In methanol; Ambient temperature;

DOI:10.1021/jo00052a046

Reference yield:

vanillin (121-33-5,8014-42-4) → 5-(2-carboxy-trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde (144735-64-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / Br₂, HOAc / 1 h / Ambient temperature

2: 98 percent / pyrrolidine / pyridine / 6 h / 100 °C

3: 1) CuSO₄*H₂O, NH₄OH, NH₂OH*HCl, 2) pyridine / 1) THF, EtOH, 2) 115 deg C, 20 h

4: 1) KCl, HCl(g) / 1) Et₂O, 0 deg C, 2) EtOH, H₂O, 50 deg C

5: 78 percent / 1N NaOH / methanol / Ambient temperature

With pyrrolidine; pyridine; hydrogenchloride; ammonium hydroxide; sodium hydroxide; potassium chloride; hydroxylamine hydrochloride; bromine; copper(II) sulfate; acetic acid; In pyridine; methanol;

DOI:10.1021/jo00052a046

Reference yield:

4-benzyloxy-3-methoxyacetophenone (1835-11-6) → 5-(2-carboxy-trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde (144735-64-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 63 percent / POCl₃ / 1) 0 deg C, 20 min, 2) 65 deg C, 10 h

2: 79 percent / NaOH / H₂O; dioxane / 2 h / 80 °C

3: 1) CuSO₄*H₂O, NH₄OH, NH₂OH*HCl, 2) pyridine / 1) THF, EtOH, 2) 115 deg C, 20 h

4: 1) KCl, HCl(g) / 1) Et₂O, 0 deg C, 2) EtOH, H₂O, 50 deg C

5: 78 percent / 1N NaOH / methanol / Ambient temperature

With pyridine; hydrogenchloride; ammonium hydroxide; sodium hydroxide; potassium chloride; hydroxylamine hydrochloride; copper(II) sulfate; trichlorophosphate; In 1,4-dioxane; methanol; water;

DOI:10.1021/jo00052a046

upstream raw materials:

5-(2-(methoxycarbonyl)-trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde

vanillin

4-benzyloxy-3-methoxyacetophenone

methyl 3-methoxy-4-hydroxy-5-bromocinnamate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 144735-64-8 5-(2-carboxy-trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran-3-carbaldehyde

Send

Send

Metric Ton KG G Pound L ML

Send

Send