Technology Process of 2-((ethoxycarbonyl)methoxy)-5-iodobenzoic acid methyl ester
There total 1 articles about 2-((ethoxycarbonyl)methoxy)-5-iodobenzoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
water; acetone;
- Guidance literature:
-
With
hydrogenchloride; potassium hydroxide;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium hexamethyldisilazane / toluene / 2 h / 0 - 25 °C
1.2: 1.5 h / 0 - 80 °C
1.3: 2.5 h / 25 - 60 °C
2.1: sodium hydride / tetrahydrofuran / 1 h / 15 - 25 °C
3.1: borane-THF / 20 h / 0 - 5 °C
4.1: hydrogenchloride / water / 2 h / 70 °C
5.1: triethylamine
6.1: copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; sodium t-butanolate / N,N-dimethyl-formamide / 15 h / 100 °C
7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 0 - 25 °C
8.1: hydrogenchloride / 1,4-dioxane
With
hydrogenchloride; copper(l) iodide; borane-THF; 2.9-dimethyl-1,10-phenanthroline; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; sodium t-butanolate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
1.1: Claisen condensation / 1.2: Claisen condensation / 1.3: Claisen condensation / 2.1: Horner-Wadsworth-Emmons olefination / 4.1: Pictet-Spengler cyclisation;
DOI:10.1016/j.bmcl.2011.11.050
