cis-3-(4-benzylpiperazinylmethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one

Base Information

Chemical Name:cis-3-(4-benzylpiperazinylmethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one
CAS No.:105150-85-4
Molecular Formula:C₂₇H₂₉N₃OS
Molecular Weight:443.613
Hs Code.:

Synonyms:cis-3-(4-benzylpiperazinylmethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cis-3-(4-benzylpiperazinylmethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one

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Technology Process of cis-3-(4-benzylpiperazinylmethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one

There total 12 articles about cis-3-(4-benzylpiperazinylmethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 100-44-7
benzyl chloride

: 72293-28-8,117553-61-4,117553-83-0
(-)-cis-2,3-dihydro-2-phenyl-3-piperazinylmethyl-1,5-benzothiazepin-4(5H)-one

: 105150-85-4
cis-3-(4-benzylpiperazinylmethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 4h;
DOI:10.1248/cpb.36.551

Reference yield:

: 72293-07-3
ethyl 3-(2-aminophenylthio)-2-ethoxycarbonyl-3-phenylpropionate

: 105150-85-4
cis-3-(4-benzylpiperazinylmethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 44 percent / triethylamine hydrochloride / 3 h / 180 °C

2: 92 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: 93 percent / pyridine / 2 h / Ambient temperature

4: 19 percent / pyridine / 3.5 h / 110 °C

5: 76 percent / K₂CO₃ / dimethylformamide / 4 h / 80 - 90 °C

With pyridine; lithium aluminium tetrahydride; triethylamine hydrochloride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.551

Reference yield:

: 5292-53-5
diethyl benzalmalonate

: 105150-85-4
cis-3-(4-benzylpiperazinylmethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 35 percent / triethylamine hydrochloride / 3.5 h / 180 °C

2: 92 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: 93 percent / pyridine / 2 h / Ambient temperature

4: 19 percent / pyridine / 3.5 h / 110 °C

5: 76 percent / K₂CO₃ / dimethylformamide / 4 h / 80 - 90 °C

With pyridine; lithium aluminium tetrahydride; triethylamine hydrochloride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.551