4-[[4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl]oxy]-3,5-difluorobenzonitrile

Base Information

Chemical Name:4-[[4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl]oxy]-3,5-difluorobenzonitrile
CAS No.:1242016-00-7
Molecular Formula:C₁₈H₁₁ClF₃N₃O
Molecular Weight:377.753
Hs Code.:

Synonyms:4-[[4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl]oxy]-3,5-difluorobenzonitrile

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Chemical Property of 4-[[4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl]oxy]-3,5-difluorobenzonitrile

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Technology Process of 4-[[4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl]oxy]-3,5-difluorobenzonitrile

There total 4 articles about 4-[[4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl]oxy]-3,5-difluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242020-20-7
3,5-difluoro-4-[(4-iodo-1,3-dimethyl-1H-pyrazol-5-yl)oxy]benzonitrile

2-chloro-4-fluorophenylboronic acid: 313545-72-1
2-chloro-4-fluorophenylboronic acid

: 1242016-00-7
4-[[4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl]oxy]-3,5-difluorobenzonitrile

Guidance literature:: With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; for 5h; Reflux;

Reference yield:

: 134227-45-5
3,4,5-trifluorobenzonitrile

: 1242016-00-7
4-[[4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl]oxy]-3,5-difluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C / Inert atmosphere

2: N-iodo-succinimide / acetonitrile / 2 h / Reflux

3: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 5 h / Reflux

With N-iodo-succinimide; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 2749-59-9
1,3-dimethyl-5-pyrazolone

: 1242016-00-7
4-[[4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl]oxy]-3,5-difluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C / Inert atmosphere

2: N-iodo-succinimide / acetonitrile / 2 h / Reflux

3: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 5 h / Reflux

With N-iodo-succinimide; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;