(S)-N²-[1-(4-fluorophenyl)ethyl]-4-(imidazooxazole-5-yl)-N⁶-(aminopyrazine-2-yl)-2,6-diamine

Base Information

• Chemical Name: (S)-N²-[1-(4-fluorophenyl)ethyl]-4-(imidazooxazole-5-yl)-N⁶-(aminopyrazine-2-yl)-2,6-diamine
• CAS No.: 1239358-92-9
• Molecular Formula: C₂₀H₁₇FN₆O
• Molecular Weight: 376.393

Synonyms:(S)-N²-[1-(4-fluorophenyl)ethyl]-4-(imidazooxazole-5-yl)-N⁶-(aminopyrazine-2-yl)-2,6-diamine

Chemical Property of (S)-N²-[1-(4-fluorophenyl)ethyl]-4-(imidazooxazole-5-yl)-N⁶-(aminopyrazine-2-yl)-2,6-diamine

Chemical Property:

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Technology Process of (S)-N²-[1-(4-fluorophenyl)ethyl]-4-(imidazooxazole-5-yl)-N⁶-(aminopyrazine-2-yl)-2,6-diamine

There total 3 articles about (S)-N²-[1-(4-fluorophenyl)ethyl]-4-(imidazooxazole-5-yl)-N⁶-(aminopyrazine-2-yl)-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Aminopyrazine (5049-61-6) + (S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(oxazol-5-yl)pyridin-2-amine (1239363-46-2) → (S)-N2-[1-(4-fluorophenyl)ethyl]-4-(imidazooxazole-5-yl)-N6-(aminopyrazine-2-yl)-2,6-diamine (1239358-92-9)

Guidance literature:

With sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

2,6-dichloropyridine-4-carbaldehyde (113293-70-2) → (S)-N2-[1-(4-fluorophenyl)ethyl]-4-(imidazooxazole-5-yl)-N6-(aminopyrazine-2-yl)-2,6-diamine (1239358-92-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / methanol / 0.5 h / 50 °C

2: palladium diacetate; caesium carbonate / 1.5 h / 100 °C / Inert atmosphere

3: sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos / toluene / 1.5 h / 89 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; palladium diacetate; potassium carbonate; caesium carbonate; sodium t-butanolate; XPhos; In methanol; toluene;

Reference yield:

5-(2,6-dichloro-4-yl)oxazole (1239362-92-5) → (S)-N2-[1-(4-fluorophenyl)ethyl]-4-(imidazooxazole-5-yl)-N6-(aminopyrazine-2-yl)-2,6-diamine (1239358-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; caesium carbonate / 1.5 h / 100 °C / Inert atmosphere

2: sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos / toluene / 1.5 h / 89 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; palladium diacetate; caesium carbonate; sodium t-butanolate; XPhos; In toluene;

upstream raw materials:

2-Aminopyrazine

(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(oxazol-5-yl)pyridin-2-amine

2,6-dichloropyridine-4-carbaldehyde

5-(2,6-dichloro-4-yl)oxazole

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