11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-12,13-dione

Base Information

• Chemical Name: 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-12,13-dione
• CAS No.: 192212-94-5
• Molecular Formula: C₂₃H₂₅NO₅
• Molecular Weight: 395.455
• Mol file: 192212-94-5.mol

Synonyms:11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-12,13-dione

Chemical Property of 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-12,13-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-12,13-dione

There total 5 articles about 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-12,13-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-carbomethoxy-6-methoxy-2-tetralone (13838-42-1) → 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-triene-12,13-dione (192212-94-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent / K₂CO₃ / acetone / 3 h / Heating

2: 16 percent / acetic acid; H₂O / 3 h / Heating

3: dioxane / 4 h / Ambient temperature

4: DBU / toluene / Heating

With potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; water; acetic acid; acetone; toluene;

DOI:10.1021/jo9700787

Reference yield:

6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid methyl ester (151533-44-7) → 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-triene-12,13-dione (192212-94-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 16 percent / acetic acid; H₂O / 3 h / Heating

2: dioxane / 4 h / Ambient temperature

3: DBU / toluene / Heating

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; water; acetic acid; toluene;

DOI:10.1021/jo9700787

Reference yield:

6-Methoxy-1-methyl-3-methylene-2-oxo-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid 2,4-dimethoxy-benzylamide → 11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-triene-12,13-dione (192212-94-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; Yield given; Heating;

DOI:10.1021/jo9700787

upstream raw materials:

2,4-Dimethoxybenzylamine

1-carbomethoxy-6-methoxy-2-tetralone

6-Methoxy-1-methyl-3-methylene-2-oxo-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid methyl ester

6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid methyl ester

Downstream raw materials:

11-(2,4-Dimethoxy-benzyl)-5-methoxy-1-methyl-11-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-12-one