1,4-bis(5'-(pyridin-2-yl)-1'H-1',2',4'-triazol-3'-yl)-2,5-dimethoxybenzene

Base Information

• Chemical Name: 1,4-bis(5'-(pyridin-2-yl)-1'H-1',2',4'-triazol-3'-yl)-2,5-dimethoxybenzene
• CAS No.: 443643-12-7
• Molecular Formula: C₂₂H₁₈N₈O₂
• Molecular Weight: 426.437
• Mol file: 443643-12-7.mol

Synonyms:1,4-bis(5'-(pyridin-2-yl)-1'H-1',2',4'-triazol-3'-yl)-2,5-dimethoxybenzene

Chemical Property of 1,4-bis(5'-(pyridin-2-yl)-1'H-1',2',4'-triazol-3'-yl)-2,5-dimethoxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-bis(5'-(pyridin-2-yl)-1'H-1',2',4'-triazol-3'-yl)-2,5-dimethoxybenzene

There total 4 articles about 1,4-bis(5'-(pyridin-2-yl)-1'H-1',2',4'-triazol-3'-yl)-2,5-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

1,4-bis(acylpyridin-2'-ylamidrazone)-2,5-dimethoxybenzene (443643-19-4) → 1,4-bis(5'-(pyridin-2-yl)-1'H-1',2',4'-triazol-3'-yl)-2,5-dimethoxybenzene (443643-12-7)

Guidance literature:

With ethylene glycol; Heating;

DOI:10.1039/b108728m

Reference yield:

2,5-dimethoxyterephthalic acid (21004-11-5) → 1,4-bis(5'-(pyridin-2-yl)-1'H-1',2',4'-triazol-3'-yl)-2,5-dimethoxybenzene (443643-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: PCl₅ / Heating

2: 67 percent / Na₂CO₃ / tetrahydrofuran / 24 h / 0 °C

3: 54 percent / ethylene glycol / Heating

With phosphorus pentachloride; sodium carbonate; ethylene glycol; In tetrahydrofuran;

DOI:10.1039/b108728m

Reference yield:

diethyl-2,5-dimethoxy-1,4-benzenedicarboxylate (173267-23-7) → 1,4-bis(5'-(pyridin-2-yl)-1'H-1',2',4'-triazol-3'-yl)-2,5-dimethoxybenzene (443643-12-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / KOH / ethane-1,2-diol / 100 °C

2: PCl₅ / Heating

3: 67 percent / Na₂CO₃ / tetrahydrofuran / 24 h / 0 °C

4: 54 percent / ethylene glycol / Heating

With potassium hydroxide; phosphorus pentachloride; sodium carbonate; ethylene glycol; In tetrahydrofuran; ethylene glycol;

DOI:10.1039/b108728m

upstream raw materials:

1,4-bis(acylpyridin-2'-ylamidrazone)-2,5-dimethoxybenzene

diethyl-2,5-dimethoxy-1,4-benzenedicarboxylate

2,5-dimethoxyterephthalic acid

2,5-dimethoxyterephthaloyl dichloride