3,4-bis(benzyloxy)-6-[(E)-2-[4-(trifluoromethyl)phenyl]-ethenyl]pyridazine

Base Information

• Chemical Name: 3,4-bis(benzyloxy)-6-[(E)-2-[4-(trifluoromethyl)phenyl]-ethenyl]pyridazine
• CAS No.: 1425512-05-5
• Molecular Formula: C₂₇H₂₁F₃N₂O₂
• Molecular Weight: 462.471
• Mol file: 1425512-05-5.mol

Synonyms:3,4-bis(benzyloxy)-6-[(E)-2-[4-(trifluoromethyl)phenyl]-ethenyl]pyridazine

Chemical Property of 3,4-bis(benzyloxy)-6-[(E)-2-[4-(trifluoromethyl)phenyl]-ethenyl]pyridazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-bis(benzyloxy)-6-[(E)-2-[4-(trifluoromethyl)phenyl]-ethenyl]pyridazine

There total 4 articles about 3,4-bis(benzyloxy)-6-[(E)-2-[4-(trifluoromethyl)phenyl]-ethenyl]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3,4-bis(benzyloxy)-6-chloropyridazine (55826-72-7) + trans-2-[4-(trifluoromethyl)phenyl]vinylboronic acid (352525-91-8) → 3,4-bis(benzyloxy)-6-[(E)-2-[4-(trifluoromethyl)phenyl]-ethenyl]pyridazine (1425512-05-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 120 ℃; Inert atmosphere; Microwave irradiation;

Reference yield:

C19H11F3N2O2 (1436848-88-2) + benzyl alcohol (100-51-6,185532-71-2) → 3,4-bis(benzyloxy)-6-[(E)-2-[4-(trifluoromethyl)phenyl]-ethenyl]pyridazine (1425512-05-5)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; toluene; at 0 - 120 ℃; for 4.5h;

DOI:10.1021/jm400095b

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 3,4-bis(benzyloxy)-6-[(E)-2-[4-(trifluoromethyl)phenyl]-ethenyl]pyridazine (1425512-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / mineral oil; tetrahydrofuran / 17.17 h / 0 - 25 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 120 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water; mineral oil;

upstream raw materials:

benzyl alcohol

3,4-bis(benzyloxy)-6-chloropyridazine

trans-2-[4-(trifluoromethyl)phenyl]vinylboronic acid

C₁₉H₁₁F₃N₂O₂

Downstream raw materials:

4-hydroxy-6-{2-[4-(trifluoromethyl)phenyl]ethyl}pyridazine-3(2H)-one